The role of transcription-independent damage signals in the initiation of epithelial wound healing

JV Cordeiro, A Jacinto - Nature reviews Molecular cell biology, 2013 - nature.com
Wound healing is an essential biological process that comprises sequential steps aimed at
restoring the architecture and function of damaged cells and tissues. This process begins …

Wound repair: toward understanding and integration of single-cell and multicellular wound responses

KJ Sonnemann, WM Bement - Annual review of cell and …, 2011 - annualreviews.org
The importance of wound healing to medicine and biology has long been evident, and
consequently, wound healing has been the subject of intense investigation for many years …

High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae

M Wang, Q Hu, T Lv, Y Wang, Q Lan, R Xiang, Z Tu… - Developmental Cell, 2022 - cell.com
Drosophila has long been a successful model organism in multiple biomedical fields. Spatial
gene expression patterns are critical for the understanding of complex pathways and …

The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes

J Jacobs, M Atkins, K Davie, H Imrichova, L Romanelli… - Nature …, 2018 - nature.com
Transcriptional enhancers function as docking platforms for combinations of transcription
factors (TFs) to control gene expression. How enhancer sequences determine nucleosome …

[HTML][HTML] A Gαq-Ca2+ signaling pathway promotes actin-mediated epidermal wound closure in C. elegans

S Xu, AD Chisholm - Current biology, 2011 - cell.com
Background Repair of skin wounds is essential for animals to survive in a harsh
environment, yet the signaling pathways initiating wound repair in vivo remain little …

Initiating a regenerative response; cellular and molecular features of wound healing in the cnidarian Nematostella vectensis

TQ DuBuc, N Traylor-Knowles, MQ Martindale - BMC biology, 2014 - Springer
Background Wound healing is the first stage of a series of cellular events that are necessary
to initiate a regenerative response. Defective wound healing can block regeneration even in …

Damage signals in the insect immune response

R Krautz, B Arefin, U Theopold - Frontiers in plant science, 2014 - frontiersin.org
Insects and mammals share an ancient innate immune system comprising both humoral and
cellular responses. The insect immune system consists of the fat body, which secretes …

Drosophila as a model of wound healing and tissue regeneration in vertebrates

Y Belacortu, N Paricio - Developmental Dynamics, 2011 - Wiley Online Library
Understanding the molecular basis of wound healing and regeneration in vertebrates is one
of the main challenges in biology and medicine. This understanding will lead to medical …

Immune Response in the Barrier Epithelia: Lessons from the Fruit Fly Drosophila melanogaster

MM Davis, Y Engström - Journal of innate immunity, 2012 - karger.com
The barrier epithelia of multicellular organisms frequently come into direct contact with
microorganisms and thus need to fulfill the important task of preventing the penetration of …

[HTML][HTML] Genome-wide transcriptional analysis of Drosophila larvae infected by entomopathogenic nematodes shows involvement of complement, recognition and …

B Arefin, L Kucerova, P Dobes, R Markus… - Journal of Innate …, 2014 - karger.com
Heterorhabditis bacteriophora is an entomopathogenic nematode (EPN) which infects its
host by accessing the hemolymph where it releases endosymbiotic bacteria of the species …