Fast time scale dynamics of protein backbones: NMR relaxation methods, applications, and functional consequences
VA Jarymowycz, MJ Stone - Chemical reviews, 2006 - ACS Publications
Over the past 15 years there has been an explosion of research on the dynamical properties
of proteins, largely driven by the emergence of a handful of techniques that are sensitive to …
of proteins, largely driven by the emergence of a handful of techniques that are sensitive to …
Fungal ribotoxins: molecular dissection of a family of natural killers
J Lacadena, E Álvarez-García… - FEMS microbiology …, 2007 - academic.oup.com
RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …
Revealing the structural origin of the redox-Bohr effect: the first solution structure of a cytochrome from Geobacter sulfurreducens
Gs (Geobacter sulfurreducens) can transfer electrons to the exterior of its cells, a property
that makes it a preferential candidate for the development of biotechnological applications …
that makes it a preferential candidate for the development of biotechnological applications …
The insecticidal protein hirsutellin A from the mite fungal pathogen Hirsutella thompsonii is a ribotoxin
E Herrero‐Galán, J Lacadena… - Proteins: Structure …, 2008 - Wiley Online Library
The mite fungal pathogen Hirsutella thompsonii produces a single polypeptide chain,
insecticidal protein named hirsutellin A (HtA) that is composed of 130 amino acid residues …
insecticidal protein named hirsutellin A (HtA) that is composed of 130 amino acid residues …
The therapeutic potential of fungal ribotoxins
N Carreras-Sangrà, E Álvarez-García… - Current …, 2008 - ingentaconnect.com
Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific
activity on a conserved region of the larger molecule of rRNA, known as the sarcin-ricin loop …
activity on a conserved region of the larger molecule of rRNA, known as the sarcin-ricin loop …
[HTML][HTML] Modeling the highly specific ribotoxin recognition of ribosomes
F García-Mayoral, L García-Ortega, E Álvarez-García… - FEBS letters, 2005 - Elsevier
The three-dimensional structures of the α-sarcin ribotoxin and its Δ (7–22) deletion mutant,
both complexed with a 20-mer oligonucleotide mimicking the sarcin/ricin loop (SRL) of the …
both complexed with a 20-mer oligonucleotide mimicking the sarcin/ricin loop (SRL) of the …
Production and characterization of a noncytotoxic deletion variant of the Aspergillus fumigatus allergen Aspf1 displaying reduced IgE binding
Aspergillus fumigatus is responsible for many allergic respiratory diseases, the most notable
of which− due to its severity− is allergic bronchopulmonary aspergillosis. Aspf1 is a major …
of which− due to its severity− is allergic bronchopulmonary aspergillosis. Aspf1 is a major …
NMR structure of the noncytotoxic α‐sarcin mutant Δ (7‐22): The importance of the native conformation of peripheral loops for activity
MF García‐Mayoral, L García‐Ortega, MP Lillo… - Protein …, 2004 - Wiley Online Library
Abstract The deletion mutant Δ (7‐22) of α‐sarcin, unlike its wild‐type protein counterpart,
lacks the specific ability to degrade rRNA in intact ribosomes and exhibits an increased …
lacks the specific ability to degrade rRNA in intact ribosomes and exhibits an increased …
Structural mobility of the monomeric C‐terminal domain of the HIV‐1 capsid protein
LA Alcaraz, M Del Alamo, MG Mateu… - The FEBS …, 2008 - Wiley Online Library
The capsid protein of HIV‐1 (p24)(CA) forms the mature capsid of the human
immunodeficiency virus. Capsid assembly involves hexamerization of the N‐terminal …
immunodeficiency virus. Capsid assembly involves hexamerization of the N‐terminal …
pH-dependent conformational stability of the ribotoxin α-sarcin and four active site charge substitution variants
MF García-Mayoral, Á Martínez del Pozo… - Biochemistry, 2006 - ACS Publications
α-Sarcin is an exquisitely specific ribonuclease that binds and cleaves a single
phosphodiester bond in the large rRNA of the eukaryotic ribosome, inactivating it. To better …
phosphodiester bond in the large rRNA of the eukaryotic ribosome, inactivating it. To better …