[HTML][HTML] Lung microbiome: new insights into the pathogenesis of respiratory diseases

R Li, J Li, X Zhou - Signal transduction and targeted therapy, 2024 - nature.com
The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …

Hypersensitivity pneumonitis: Current concepts in pathogenesis, diagnosis, and treatment

H Barnes, L Troy, CT Lee, A Sperling, M Strek… - Allergy, 2022 - Wiley Online Library
Hypersensitivity pneumonitis is an immune‐mediated interstitial lung disease caused by an
aberrant response to an inhaled exposure, which results in mostly T cell–mediated …

[HTML][HTML] Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease

B Vijayakumar, K Boustani, PP Ogger, A Papadaki… - Immunity, 2022 - cell.com
Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for
many months. We delineated the immune-proteomic landscape in the airways and …

[HTML][HTML] Enhanced IL-1β release following NLRP3 and AIM2 inflammasome stimulation is linked to mtROS in airway macrophages in pulmonary fibrosis

A Trachalaki, E Tsitoura, S Mastrodimou… - Frontiers in …, 2021 - frontiersin.org
Fibrotic Interstitial lung diseases (ILDs) are complex disorders of variable clinical behaviour.
The majority of them cause significant morbidity, whilst Idiopathic Pulmonary Fibrosis (IPF) is …

[HTML][HTML] S100A12 as biomarker of disease severity and prognosis in patients with idiopathic pulmonary fibrosis

Y Li, Y He, S Chen, Q Wang, Y Yang, D Shen… - Frontiers in …, 2022 - frontiersin.org
Background Idiopathic pulmonary fibrosis (IPF) is one of interstitial lung diseases (ILDs) with
poor prognosis. S100 calcium binding protein A12 (S100A12) has been reported as a …

[HTML][HTML] Pharmacomicrobiology of methotrexate in rheumatoid arthritis: gut microbiome as predictor of therapeutic response

H Yan, R Su, H Xue, C Gao, X Li, C Wang - Frontiers in Immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a disabling autoimmune disease with invasive arthritis as the
main manifestation and synovitis as the basic pathological change, which can cause …

Genetic risk factors for idiopathic pulmonary fibrosis: insights into immunopathogenesis

JE Michalski, DA Schwartz - Journal of Inflammation Research, 2021 - Taylor & Francis
Idiopathic pulmonary fibrosis is an etiologically complex interstitial lung disease
characterized by progressive scarring of the lungs with a subsequent decline in lung …

[HTML][HTML] The epithelial-immune crosstalk in pulmonary fibrosis

T Planté-Bordeneuve, C Pilette, A Froidure - Frontiers in immunology, 2021 - frontiersin.org
Interactions between the lung epithelium and the immune system involve a tight regulation
to prevent inappropriate reactions and have been connected to several pulmonary diseases …

[HTML][HTML] Lung microbiome in idiopathic pulmonary fibrosis and other interstitial lung diseases

F Amati, A Stainer, M Mantero, A Gramegna… - International journal of …, 2022 - mdpi.com
Interstitial lung diseases represent a heterogeneous and wide group of diseases in which
factors leading to disease initiation and progression are not fully understood. Recent …

[HTML][HTML] Horizontal transmission of gut microbiota attenuates mortality in lung fibrosis

SJ Gurczynski, JH Lipinski, J Strauss, S Alam… - JCI insight, 2024 - ncbi.nlm.nih.gov
Pulmonary fibrosis is a chronic and often fatal disease. The pathogenesis is characterized
by aberrant repair of lung parenchyma, resulting in loss of physiological homeostasis …