Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …

The notion that heart attacks develop from coronary-artery stenosis is an oversimplification
of a process involving lipid metabolism, inflammation, macrophage activation, collagen …

Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and
loss of productive life years worldwide. Research into the disease has led to many …

Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …

Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in
the arterial wall. Rather, the initiation and progression of atherosclerotic lesions is currently …

According to the traditional view, atherosclerosis results from a passive buildup of
cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune …

1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Background Elevated lipoprotein-associated phospholipase A2 activity promotes the
development of vulnerable atherosclerotic plaques, and elevated plasma levels of this …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …