Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …

According to the free radical theory, aging can be considered as a progressive, inevitable
process partially related to the accumulation of oxidative damage into biomolecules–nucleic …

Mitochondrial dysfunction contributes to many human degenerative diseases but specific
treatments are hampered by the difficulty of delivering bioactive molecules to mitochondria …

Huntington disease is an autosomal dominant neurodegenerative disease with no effective
treatment. Minocycline is a tetracycline derivative with proven safety. After ischemia …

The endoplasmic reticulum (ER) regulates protein synthesis, protein folding and trafficking,
cellular responses to stress and intracellular calcium (Ca 2+) levels. Alterations in Ca 2+ …

There is a large body of evidence implicating oxidative damage in the pathogenesis of both
normal aging and neurodegenerative diseases. Oxidative damage to proteins has been well …

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no
single specific protein-protein interaction of mutant huntingtin has emerged as the …

Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for
multiple essential functions in the body. A recent study on cows fed genetically modified …

Mitochondrial dysfunction has been described as an early pathological mechanism
delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a …

Although a direct causative pathway from the gene mutation to the selective neostriatal
neurodegeneration remains unclear in Huntington's disease (HD), one putative pathological …