Plant-based COVID-19 vaccines: current status, design, and development strategies of candidate vaccines

PM Maharjan, S Choe - Vaccines, 2021 - mdpi.com
The prevalence of the coronavirus disease 2019 (COVID-19) pandemic in its second year
has led to massive global human and economic losses. The high transmission rate and the …

Contributions of the international plant science community to the fight against human infectious diseases–part 1: epidemic and pandemic diseases

M Lobato Gomez, X Huang, D Alvarez… - Plant biotechnology …, 2021 - Wiley Online Library
Infectious diseases, also known as transmissible or communicable diseases, are caused by
pathogens or parasites that spread in communities by direct contact with infected individuals …

N-glycosylation of the SARS-CoV-2 receptor binding domain is important for functional expression in plants

YJ Shin, J König-Beihammer, U Vavra… - Frontiers in Plant …, 2021 - frontiersin.org
Nicotiana benthamiana is used worldwide as production host for recombinant proteins.
Many recombinant proteins such as monoclonal antibodies, growth factors or viral antigens …

[HTML][HTML] Principles of SARS-CoV-2 glycosylation

H Chawla, E Fadda, M Crispin - Current Opinion in Structural Biology, 2022 - Elsevier
The structure and post-translational processing of the SARS-CoV-2 spike glycoprotein (S) is
intimately associated with the function of the virus and of sterilising vaccines. The surface of …

Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity

B Shanmugaraj, N Khorattanakulchai, C Panapitakkul… - Vaccine, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is an acute respiratory illness caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The prevention of SARS …

Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii

AJ Berndt, TN Smalley, B Ren, R Simkovsky, A Badary… - PloS one, 2021 - journals.plos.org
Recombinant production of viral proteins can be used to produce vaccine antigens or
reagents to identify antibodies in patient serum. Minimally, these proteins must be correctly …

Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) by SARS-CoV-2 in non-hospitalised HIV-infected patients

H Lambarey, MJ Blumenthal, A Chetram… - …, 2024 - thelancet.com
Summary Background While acute SARS-CoV-2 infection and associated inflammation
resulted in substantial morbidity and mortality during the COVID-19 pandemic, particularly in …

Performance of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies in South Africa

MP Gededzha, N Mampeule, S Jugwanth, N Zwane… - PloS one, 2021 - journals.plos.org
Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) has been identified as
the causative agent for causing the clinical syndrome of COVID-19. Accurate detection of …

Plant-expressed receptor binding domain of the SARS-CoV-2 spike protein elicits humoral immunity in mice

PM Maharjan, J Cheon, J Jung, H Kim, J Lee, M Song… - Vaccines, 2021 - mdpi.com
The current 15-month coronavirus disease-19 (COVID-19) pandemic caused by SARS-CoV-
2 has accounted for 3.77 million deaths and enormous worldwide social and economic …

Era of molecular diagnostics techniques before and after the COVID-19 pandemic

AM Alamri, FA Alkhilaiwi, N Ullah Khan - Current Issues in Molecular …, 2022 - mdpi.com
Despite the growth of molecular diagnosis from the era of Hippocrates, the emergence of
COVID-19 is still remarkable. The previously used molecular techniques were not rapid …