The “protein folding problem” consists of three closely related puzzles:(a) What is the folding
code?(b) What is the folding mechanism?(c) Can we predict the native structure of a protein …

Recent advance in large-scale genome se-quencing has generated a huge volume of pro-
tein sequences. In order to timely utilize the in-formation hidden in these newly discovered …

Identification and study of the main principles underlying the kinetics and thermodynamics of
protein folding generate a new insight into the factors that control this process. Statistical …

Developing an efficient method for determination of the DNA-binding proteins, due to their
vital roles in gene regulation, is becoming highly desired since it would be invaluable to …

As was noted in our recent review, 1 the protein folding field underwent a cyclic
development. Initially, protein folding was viewed as a strictly experimental field belonging to …

Visualizing the navigation of an ensemble of unfolded molecules through the bumpy energy
landscape in search of the native state gives a pictorial view of biomolecular folding. This …

The chaperonins are ubiquitous and essential nanomachines that assist in protein folding in
an ATP-driven manner. They consist of two back-to-back stacked oligomeric rings with …

Coarse-grained, self-contained polymer models are powerful tools in the study of protein
folding. They are also essential to assess predictions from less rigorous theoretical …

▪ Abstract Simulation of protein folding has come a long way in five years. Notably, new
quantitative comparisons with experiments for small, rapidly folding proteins have become …

Using mass spectrometry (MS) to obtain information about a higher order structure of protein
requires that a protein's structural properties are encoded into the mass of that protein …