Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy
S Xu, X Wu, J Zhu, Q Wu, L Gao… - Drug Development …, 2024 - Wiley Online Library
The development of anticancer drugs that target different organelles has received extensive
attention due to the characteristics of cancer recurrence, metastasis, and drug resistance …
attention due to the characteristics of cancer recurrence, metastasis, and drug resistance …
The dual effect of endoplasmic reticulum stress in digestive system tumors and intervention of Chinese botanical drug extracts: a review
J Zhang, Y Chen, B Chen, D Sun, Z Sun… - Frontiers in …, 2024 - frontiersin.org
Endoplasmic reticulum (ER) homeostasis is essential for maintaining human health, and
once imbalanced, it will trigger endoplasmic reticulum stress (ERS), which participates in the …
once imbalanced, it will trigger endoplasmic reticulum stress (ERS), which participates in the …
Pan-cancer analysis and in vitro validation of the oncogenic and prognostic roles of AURKA in human cancers
C Yang, PS Plum, I Gockel, R Thieme - Frontiers in Oncology, 2023 - frontiersin.org
Background Aurora kinase A (AURKA) plays a pivotal role in regulating cell mitosis and
tumor progression. However, its prognostic significance across diverse cancer types …
tumor progression. However, its prognostic significance across diverse cancer types …
Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma
Objective Chronic gastro-oesophageal reflux disease, where acidic bile salts (ABS) reflux
into the oesophagus, is the leading risk factor for oesophageal adenocarcinoma (EAC). We …
into the oesophagus, is the leading risk factor for oesophageal adenocarcinoma (EAC). We …
Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer
CC Ayala-Aguilera, Y Ge, Á Lorente-Macías… - RSC Medicinal …, 2025 - pubs.rsc.org
Oesophageal cancer (OC) is one of the leading causes of cancer-related deaths worldwide.
Due in part to its high heterogeneity, OC prognosis remains poor despite the introduction of …
Due in part to its high heterogeneity, OC prognosis remains poor despite the introduction of …
Cranberry Proanthocyanidins Mitigate Reflux-Induced Transporter Dysregulation in an Esophageal Adenocarcinoma Model
We recently reported that cranberry proanthocyanidins (C-PACs) inhibit esophageal
adenocarcinoma (EAC) by 83% through reversing reflux-induced bacterial, inflammatory …
adenocarcinoma (EAC) by 83% through reversing reflux-induced bacterial, inflammatory …
[HTML][HTML] ER stress-related mRNA-lncRNA co-expression gene signature predicts the prognosis and immune implications of esophageal cancer
F Li, J Ma, C Yan, Y Qi - American Journal of Translational …, 2022 - ncbi.nlm.nih.gov
Background: Esophageal cancer (EC) is one of the most common malignant cancers in the
world. Endoplasmic reticulum (ER) stress is an adaptive response to various stress …
world. Endoplasmic reticulum (ER) stress is an adaptive response to various stress …
A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
G Gauthier-Coles - 2022 - search.proquest.com
Amino acid homeostasis is maintained by a combination of transmembrane transport
processes, metabolic pathways, protein synthesis and turnover, and signalling systems to …
processes, metabolic pathways, protein synthesis and turnover, and signalling systems to …