Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Expansion and activation of fibroblasts following cardiac injury is important for repair but
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …

Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute
myocardial infarction (MI) and to mediate long-standing fibrosis with chronic disease …

The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and
under physiological conditions. In the adult heart, activated cardiac fibroblasts also …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular
matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia …

Cardiac fibrosis remains an important health concern, but the study of fibroblast biology has
been hindered by a lack of effective means for identifying and tracking fibroblasts. Recent …