The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Immunometabolism at the interface between macrophages and pathogens

DG Russell, L Huang, BC VanderVen - Nature Reviews Immunology, 2019 - nature.com
It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Lactate signalling regulates fungal β-glucan masking and immune evasion

ER Ballou, GM Avelar, DS Childers, J Mackie… - Nature …, 2016 - nature.com
As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of
the innate immune response, and yet the commensal fungus Candida albicans is able to …

Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels

AJP Brown, GD Brown, MG Netea, NAR Gow - Trends in microbiology, 2014 - cell.com
Metabolism is integral to the pathogenicity of Candida albicans, a major fungal pathogen of
humans. As well as providing the platform for nutrient assimilation and growth in diverse …

Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans

S Biswas, P Van Dijck, A Datta - Microbiology and molecular …, 2007 - Am Soc Microbiol
Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, under certain environmental …

[HTML][HTML] An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis

C Chen, K Pande, SD French, BB Tuch, SM Noble - Cell host & microbe, 2011 - cell.com
The mammalian gastrointestinal tract and bloodstream are highly disparate biological
niches that differ in concentrations of nutrients such as iron. However, some commensal …

The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH

S Vylkova, AJ Carman, HA Danhof, JR Collette, H Zhou… - MBio, 2011 - Am Soc Microbiol
ABSTRACT pH homeostasis is critical for all organisms; in the fungal pathogen Candida
albicans, pH adaptation is critical for virulence in distinct host niches. We demonstrate that …

Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen

IV Ene, AK Adya, S Wehmeier, AC Brand… - Cellular …, 2012 - Wiley Online Library
The survival of all microbes depends upon their ability to respond to environmental
challenges. To establish infection, pathogens such as C andida albicans must mount …

Dynamic fungal cell wall architecture in stress adaptation and immune evasion

A Hopke, AJP Brown, RA Hall, RT Wheeler - Trends in microbiology, 2018 - cell.com
Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-
risk immunocompromised population created by advances in modern medicine and the …

Candida survival strategies

M Polke, B Hube, ID Jacobsen - Advances in Applied Microbiology, 2015 - Elsevier
Only few Candida species, eg, Candida albicans, Candida glabrata, Candida dubliniensis,
and Candida parapsilosis, are successful colonizers of a human host. Under certain …