Alternative Splicing (AS) programs serve as instructive signals of cell type specificity,
particularly within the brain, which comprises dozens of molecularly and functionally distinct …

A growing body of work suggests that the material properties of biomolecular condensates
ensuing from liquid–liquid phase separation change with time. How this aging process is …

Gene expression is a multistep process and crosstalk among regulatory layers plays an
important role in coordinating gene expression. To identify functionally relevant gene …

Abstract The human SASS6 (I62T) missense mutation has been linked with the incidence of
primary microcephaly in a Pakistani family, although the mechanisms by which this mutation …

Profiling the transcriptomes of single cells without sacrificing spatial information is a major
goal of the field of spatial transcriptomics, but current technologies require tradeoffs between …

The highly-conserved stomatin domain has been identified in genes throughout all classes
of life. In animals, different stomatin domain-encoding genes have been implicated in the …

Alternative splicing is a key mechanism that shapes neuronal transcriptomes, helping to
define neuronal identity and modulate function. Here, we present an atlas of alternative …

Profiling gene expression in single neurons using single-cell RNA-Seq is a powerful method
for understanding the molecular diversity of the nervous system. Profiling alternative splicing …

Comprised of only 20 cells, the Caenorhabditis elegans intestine is the nexus of many life-
supporting functions, including digestion, metabolism, aging, immunity, and environmental …

A missense mutation within the human SASS6 gene has been linked with the incidence of
primary microcephaly in a Pakistani family. However, the mechanism by which this mutation …