In this review, we will discuss what is known, what is suspected, and what still remains
obscure about the central role played by coreceptor expression and usage in the …

Despite the significant progress that has been made to eliminate vertical HIV infection, more
than 150,000 children were infected with HIV in 2019, emphasizing the continued need for …

Abstract Context: The Women and Infants Transmission Study is a prospective natural
history study that has been enrolling HIV-1-infected pregnant women and their infants since …

The biological phenotype of primary human immunodeficiency virus type 1 (HIV-1) isolates
varies according to the severity of the HIV infection. Here we show that the two previously …

Understanding the mechanisms of HIV-1 transmission is crucial for the development of
effective preventive microbicides and vaccine strategies, and remains one of the main goals …

To enter target cells HIV-1 uses CD4 and a coreceptor. In vivo the coreceptor function is
provided either by CCR5 (for R5) or CXCR4 (for X4 HIV-1). Although both R5 and X4 HIV-1 …

Macrophage tropic HIV-1 is predominant during the initial viremia after person to person
transmission of HIV-1 (Zhu, T., H. Mo, N. Wang, DS Nam, Y. Cao, RA Koup, and DD Ho …

We have investigated whether the identity of the coreceptor (CCR5, CXCR4, or both) used
by primary human immunodeficiency virus type 1 (HIV-1) isolates to enter CD4+ cells …

Publisher Summary This chapter focuses on the effects of human immunodeficiency viruses
in the developing world. Acquired immunodeficiency syndrome (AIDS) has become a major …

We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1)
primary isolates for the ability to employ the following proteins as coreceptors during viral …