Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Effects of mesenchymal stem cell‐derived paracrine signals and their delivery strategies

C Chang, J Yan, Z Yao, C Zhang, X Li… - Advanced healthcare …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …

[HTML][HTML] Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine

A González-González, D García-Sánchez… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are the most frequently used stem cells in clinical trials due
to their easy isolation from various adult tissues, their ability of homing to injury sites and …

Challenges and strategies for improving the regenerative effects of mesenchymal stromal cell-based therapies

S Baldari, G Di Rocco, M Piccoli, M Pozzobon… - International journal of …, 2017 - mdpi.com
Cell-based therapies have the potential to revolutionize current treatments for diseases with
high prevalence and related economic and social burden. Unfortunately, clinical trials have …

Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization

M Najar, R Melki, F Khalife, L Lagneaux… - Frontiers in cell and …, 2022 - frontiersin.org
Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …

Insight in Hypoxia‐Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine

A Nowak-Stępniowska, PN Osuchowska… - Stem Cells …, 2022 - Wiley Online Library
Hypoxia‐mimetic agents are new potential tools in MSC priming instead of hypoxia
incubators or chambers. Several pharmaceutical/chemical hypoxia‐mimetic agents can be …

[HTML][HTML] Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells

D Garcia-Sanchez, D Fernandez… - World journal of stem …, 2019 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are promising candidates for bone regeneration therapies
due to their plasticity and easiness of sourcing. MSC-based treatments are generally …

The effects of hypoxia on the stemness properties of human dental pulp stem cells (DPSCs)

NEMB Ahmed, M Murakami, S Kaneko… - Scientific reports, 2016 - nature.com
Recent studies have demonstrated that culture under hypoxia has beneficial effects on
mesenchymal stem cells (MSCs). However, there are limitations to achieving a stable …

The effect of culture media on large-scale expansion and characteristic of adipose tissue-derived mesenchymal stromal cells

J Czapla, S Matuszczak, K Kulik, E Wiśniewska… - Stem cell research & …, 2019 - Springer
Background Adipose tissue-derived mesenchymal stromal cells (ASCs) have been shown to
exhibit some promising properties of their use in regenerative medicine as advanced …

Mesenchymal stem cell transplantation for ischemic diseases: mechanisms and challenges

TT Van Nguyen, NB Vu, P Van Pham - Tissue Engineering and …, 2021 - Springer
Ischemic diseases are conditions associated with the restriction or blockage of blood supply
to specific tissues. These conditions can cause moderate to severe complications in …