Mass spectrometry imaging (MSI) is used in many aspects of clinical research, including
pharmacokinetics, toxicology, personalised medicine, and surgical decision-making …

Mass spectrometry imaging has advanced from a niche technique to a widely applied spatial
biology tool operating at the forefront of numerous fields, most notably making a significant …

Amyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer's disease (AD).
However, the molecular architecture of amyloid plaques in the context of fresh mammalian …

Introduction: Amyloid-beta (Aβ) pathology is the precipitating histopathological characteristic
of Alzheimer's disease (AD). Although the formation of amyloid plaques in human brains is …

β-Amyloid (Aβ) plaque formation is the major pathological hallmark of Alzheimer's disease
(AD) and constitutes a potentially critical, early inducer driving AD pathogenesis as it …

Spatial segmentation is a critical procedure in mass spectrometry imaging (MSI)-based
biochemical analysis. However, the commonly used unsupervised MSI segmentation …

Understanding of Alzheimer's disease (AD) pathophysiology requires molecular assessment
of how key pathological factors, specifically amyloid β (Aβ) plaques, influence the …

Background Mass spectrometry imaging (MSI) is a label-free analysis method for resolving
bio-molecules or pharmaceuticals in the spatial domain. It offers unique perspectives for the …

Mass spectrometry imaging vows to enable simultaneous spatially resolved investigation of
hundreds of metabolites in tissues, but it primarily relies on traditional ion images for non …

Simultaneously visualizing Amyloid-β (Aβ) plaque with its surrounding brain structures at the
subcellular level in the intact brain is essential for understanding the complex pathology of …