As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …

Cancer is the leading cause of death worldwide. Fortunately, the survival rate of cancer
continues to rise, owing to advances in cancer treatments. However, these treatments are …

STUDY QUESTION Does embryo culture medium influence pregnancy and perinatal
outcome in IVF? SUMMARY ANSWER Embryo culture media used in IVF affect treatment …

Mitochondria have been implicated as key factors regulating female reproductive processes.
Notable progress has been made in determining the role of mitochondria with respect to …

Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified
as a catalytic agent for oxidative decarboxylation of pyruvate and α-ketoglutarate. In this …

The in vitro culture systems of ovarian preantral follicles have been developed for studying
follicular and oocyte growth, for future use of immature oocytes as sources of fertilizable …

Objective Infertility is an increasingly frequent health condition, which may depend on
female or male factors. Oxidative stress (OS), resulting from a disrupted balance between …

Maternal aging results in reduced oocyte and blastocyst quality, thought to be due, in part, to
mitochondrial dysfunction and accumulation of reactive oxygen species. To reduce oxidative …

Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte.
Oxidative stress is one of the most detrimental factors affecting oocyte developmental …

Niacin, also known as vitamin B3, has a pivotal role in energy metabolism, cellular signaling
cascades regulating gene expression, and apoptosis. However, the effect of Niacin on …