Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …

The mucosal surfaces of mammals are densely colonized with microorganisms that are
commonly referred to as the commensal microbiota. It is believed that the fetus in utero is …

Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …

DNA methylation regulates eukaryotic gene expression and is extensively reprogrammed
during animal development. However, whether developmental methylation reprogramming …

Background The interplay of epigenetic processes and the intestinal microbiota may play an
important role in intestinal development and homeostasis. Previous studies have …

Epigenetic alterations are associated with normal biological processes such as aging or
differentiation. Changes in global epigenetic signatures, together with genetic alterations …

Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of
early childhood characterized by mutations activating RAS signaling. Established clinical …

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood
caused by mutations in the Ras pathway. Outcomes in JMML vary markedly from …

DNA methylation is an essential epigenetic modification for mammalian embryonic
development and biology. The DNA methylation pattern across the genome, together with …

The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …