The CCR7 chemokine axis is comprised of chemokine ligand 21 (CCL21) and chemokine
ligand 19 (CCL19) acting on chemokine receptor 7 (CCR7). This axis plays two important …

CCR7, collaborated with its ligands CCL19 and CCL21, controls extensive migratory events
in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph …

The subcutaneous route of administration has provided convenient and non-inferior delivery
of therapeutic proteins compared to intravenous infusion, but there is potential for enhanced …

Background & Aims Although chronic diarrhea and constipation are common, the treatment
is symptomatic because their pathophysiology is poorly understood. Accumulating evidence …

In the human chemokine system, interactions between the approximately 50 known
endogenous chemokine ligands and 20 known chemokine receptors (CKRs) regulate a …

CCR7 signaling directs the migration of both immune cells and cancer cells to the lymph
nodes, is involved in numerous chronic inflammatory disorders and lymph node metastases …

Despite significant progress in modern medicine and pharmacology, damage to the nervous
system with various etiologies still poses a challenge to doctors and scientists. Injuries lead …

We present a state-of-the-art virtual screening workflow aiming at the identification of novel
CC chemokine receptor 7 (CCR7) antagonists. Although CCR7 is associated with a variety …

Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease of
unknown etiology. Myofibroblasts are organized in peculiar subepithelial fibroblasts foci …

Acute graft-versus-host disease (aGVHD) remains a barrier to the success of allogeneic
hematopoietic stem cell transplantation (HSCT). Previously, we demonstrated that CC …