Precision drug delivery to the central nervous system using engineered nanoparticles
Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
Cell type-specific roles of APOE4 in Alzheimer disease
The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
Human microglial state dynamics in Alzheimer's disease progression
Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …
Bone-derived PDGF-BB drives brain vascular calcification in male mice
Brain vascular calcification is a prevalent age-related condition often accompanying
neurodegenerative and neuroinflammatory diseases. The pathogenesis of large-vessel …
neurodegenerative and neuroinflammatory diseases. The pathogenesis of large-vessel …
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery
Over the past decade, single-cell genomics technologies have allowed scalable profiling of
cell-type-specific features, which has substantially increased our ability to study cellular …
cell-type-specific features, which has substantially increased our ability to study cellular …
Astrocytes in selective vulnerability to neurodegenerative disease
Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …
Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease
S Rego, G Sanchez, S Da Mesquita - Molecular neurodegeneration, 2023 - Springer
Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice
Blood-CNS barrier disruption is a hallmark of numerous neurological disorders, yet whether
barrier breakdown is sufficient to trigger neurodegenerative disease remains unresolved …
barrier breakdown is sufficient to trigger neurodegenerative disease remains unresolved …
A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease
S Tsartsalis, H Sleven, N Fancy, F Wessely… - Nature …, 2024 - nature.com
Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer's
disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from …
disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from …