Amoebiasis

SL Stanley - The lancet, 2003 - thelancet.com
Amoebiasis is the second leading cause of death from parasitic disease worldwide. The
causative protozoan parasite, Entamoeba histolytica, is a potent pathogen. Secreting …

Proteases in parasitic diseases

JH McKerrow, C Caffrey, B Kelly… - Annu. Rev. Pathol …, 2006 - annualreviews.org
Parasitic diseases represent major global health problems of immense proportion.
Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness …

Roles and regulation of the mucus barrier in the gut

S Cornick, A Tawiah, K Chadee - Tissue barriers, 2015 - Taylor & Francis
The gastrointestinal tract is coated by a thick layer of mucus that forms the front line of innate
host defense. Mucus consists of high molecular weight glycoproteins called mucins that are …

Tissue destruction and invasion by Entamoeba histolytica

KS Ralston, WA Petri - Trends in parasitology, 2011 - cell.com
Entamoeba histolytica is the causative agent of amebiasis, a disease that is a major source
of morbidity and mortality in the developing world. The potent cytotoxic activity of the parasite …

Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel

ME Lidell, DM Moncada, K Chadee… - Proceedings of the …, 2006 - National Acad Sciences
In order for the protozoan parasite Entamoeba histolytica (Eh) to cause invasive intestinal
and extraintestinal infection, which leads to significant morbidity and mortality, it must disrupt …

Cysteine proteinases and the pathogenesis of amebiasis

X Que, SL Reed - Clinical microbiology reviews, 2000 - Am Soc Microbiol
Amebiasis is a major cause of morbidity and mortality throughout the tropical world.
Entamoeba histolytica is now recognized as a separate species from the morphologically …

Biological roles of proteases in parasitic protozoa

M Klemba, DE Goldberg - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract Proteases from a variety of protozoan parasites have been characterized at the
molecular and cellular levels, and the many roles that proteases play in these organisms are …

[HTML][HTML] Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica

K Nakada-Tsukui, T Nozaki - Frontiers in immunology, 2016 - frontiersin.org
Entamoeba histolytica is a protozoan parasite and the causative agent of amebiasis. It is
estimated approximately 1% of humans are infected with E. histolytica, resulting in an …

[HTML][HTML] Extracellular Cysteine Proteases of Key Intestinal Protozoan Pathogens—Factors Linked to Virulence and Pathogenicity

R Argüello-García, JC Carrero… - International Journal of …, 2023 - mdpi.com
Intestinal diseases caused by protistan parasites of the genera Giardia (giardiasis),
Entamoeba (amoebiasis), Cryptosporidium (cryptosporidiosis) and Blastocystis …

Structure and content of the Entamoeba histolytica genome

CG Clark, UCM Alsmark, M Tazreiter… - Advances in …, 2007 - Elsevier
The intestinal parasite Entamoeba histolytica is one of the first protists for which a draft
genome sequence has been published. Although the genome is still incomplete, it is …