Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications
GL Squadrito, EM Postlethwait… - American Journal of …, 2010 - journals.physiology.org
Industrial and transport accidents, accidental releases during recreational swimming pool
water treatment, household accidents due to mixing bleach with acidic cleaners, and, in …
water treatment, household accidents due to mixing bleach with acidic cleaners, and, in …
Mechanisms and modification of chlorine-induced lung injury in animals
AK Yadav, A Bracher, SF Doran, M Leustik… - Proceedings of the …, 2010 - atsjournals.org
Chlorine (Cl2) is a reactive oxidant gas used extensively in industrial processes. Exposure
of both humans and animals to high concentrations of Cl2 results in acute lung injury, which …
of both humans and animals to high concentrations of Cl2 results in acute lung injury, which …
[HTML][HTML] Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution
Recent studies have presented compelling evidence that it is not tissue-resident, but rather
monocyte-derived alveolar macrophages (TR-AMs and Mo-AMs, respectively) that are …
monocyte-derived alveolar macrophages (TR-AMs and Mo-AMs, respectively) that are …
[HTML][HTML] Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema
Pulmonary fibrosis and emphysema are irreversible chronic events after inhalation injury.
However, the mechanism (s) involved in their development remain poorly understood …
However, the mechanism (s) involved in their development remain poorly understood …
Sensitive detection and estimation of cell-derived peroxynitrite fluxes using fluorescein-boronate
N Rios, L Piacenza, M Trujillo, A Martinez… - Free Radical Biology …, 2016 - Elsevier
The specific and sensitive detection of peroxynitrite (ONOO−/ONOOH) in biological systems
is a great challenge due to its high reactivity towards several biomolecules. Herein, we …
is a great challenge due to its high reactivity towards several biomolecules. Herein, we …
Heme attenuation ameliorates irritant gas inhalation-induced acute lung injury
Aims: Exposure to irritant gases, such as bromine (Br2), poses an environmental and
occupational hazard that results in severe lung and systemic injury. However, the …
occupational hazard that results in severe lung and systemic injury. However, the …
Formation of chlorinated lipids post-chlorine gas exposure
DA Ford, J Honavar, CJ Albert, MA Duerr, JY Oh… - Journal of lipid …, 2016 - ASBMB
Exposure to chlorine (Cl 2) gas can occur during accidents and intentional release
scenarios. However, biomarkers that specifically indicate Cl 2 exposure and Cl 2-derived …
scenarios. However, biomarkers that specifically indicate Cl 2 exposure and Cl 2-derived …
Influenza virus infection alters ion channel function of airway and alveolar cells: mechanisms and physiological sequelae
The cystic fibrosis transmembrane conductance regulator (CFTR) and the amiloride-
sensitive epithelial sodium channels (ENaC) are located in the apical membranes of airway …
sensitive epithelial sodium channels (ENaC) are located in the apical membranes of airway …
Halogen-induced chemical injury to the mammalian cardiopulmonary systems
The halogens chlorine (Cl2) and bromine (Br2) are highly reactive oxidizing elements with
widespread industrial applications and a history of development and use as chemical …
widespread industrial applications and a history of development and use as chemical …
Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury
A Lazrak, J Creighton, Z Yu… - … of Physiology-Lung …, 2015 - journals.physiology.org
Chlorine (Cl2) inhalation induces severe oxidative lung injury and airway
hyperresponsiveness (AHR) that lead to asthmalike symptoms. When inhaled, Cl2 reacts …
hyperresponsiveness (AHR) that lead to asthmalike symptoms. When inhaled, Cl2 reacts …