Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Cell-intrinsic defences constitute the first line of defence against intracellular pathogens. The
guanosine triphosphatase RAB32 orchestrates one such defence response against the …

The etiologies of Parkinson's disease (PD) remain unclear. Some, such as certain genetic
mutations and head trauma, are widely known or easily identified. However, these causes or …

Activating mutations in leucine-rich repeat kinase 2 (LRRK2) represent the most common
cause of monogenic Parkinson's disease. LRRK2 is a large multidomain protein kinase that …

Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that orchestrates a diverse
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …

Cells maintain optimal levels of lysosome degradative activity to protect against pathogens,
clear waste, and generate nutrients. Here, we show that LRRK2, a protein that is tightly …

Chronic manganese (Mn) exposure can lead to manganism, a neurological disorder sharing
common symptoms with Parkinson's disease (PD). Studies have shown that Mn can …

Increasing evidence has shown that gut dysbacteriosis may play a crucial role in
neuroinflammation in Parkinson's disease (PD). However, the specific mechanisms that link …

The brain-and body-first models of Lewy body disorders predict that aggregated alpha-
synuclein pathology usually begins in either the olfactory system or the enteric nervous …