[HTML][HTML] Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know

WM Zelek, RA Harrison - Immunobiology, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …

[HTML][HTML] Local complement activation and modulation in mucosal immunity

DH Kulkarni, M Starick, RA Alburquerque… - Mucosal …, 2024 - Elsevier
The complement system is an evolutionarily conserved arm of innate immunity, which forms
one of the first lines of host response to pathogens, and assists in the clearance of debris. A …

Genetic justification of COVID‐19 patient outcomes using DERGA, a novel data ensemble refinement greedy algorithm

PG Asteris, AH Gandomi, DJ Armaghani… - Journal of Cellular …, 2024 - Wiley Online Library
Complement inhibition has shown promise in various disorders, including COVID‐19. A
prediction tool including complement genetic variants is vital. This study aims to identify …

Levels of complement components in children with acute COVID-19 or multisystem inflammatory syndrome

A Rajamanickam, PK Nathella… - JAMA Network …, 2023 - jamanetwork.com
Importance Multisystem inflammatory syndrome in children (MIS-C) is a severe and
unrestrained inflammatory response with multiorgan involvement, which occurs within a few …

Rare genetic variants involved in multisystem inflammatory syndrome in children: a multicenter Brazilian cohort study

BCSD Reis, R Soares Faccion… - Frontiers in cellular …, 2023 - frontiersin.org
Introduction Despite the existing data on the Multisystem Inflammatory Syndrome in Children
(MIS-C), the factors that determine these patients evolution remain elusive. Answers may lie …

What is the role of complement in bystander hemolysis? Old concept, new insights

P Evangelidis, N Evangelidis, E Vlachaki… - Expert Review of …, 2024 - Taylor & Francis
Introduction Bystander hemolysis occurs when antigen-negative red blood cells (RBCs) are
lysed by the complement system. Many clinical entities including passenger lymphocyte …