The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …

Recompensation has gained increasing attention in the field of cirrhosis, particularly in
chronic liver disease with a definite aetiology. The current global prevalence of obesity and …

Background & Aims Acute decompensation (AD) of cirrhosis is defined as the acute
development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or …

Background & Aims Acute decompensation (AD) of cirrhosis may present without acute-on-
chronic liver failure (ACLF)(AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure …

Cirrhosis–the common end-stage of chronic liver disease–is associated with a cascade of
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …

Renal dysfunction is a common, life-threatening complication occurring in patients with liver
disease. Hepatorenal syndrome (HRS) has been defined as a purely “functional” type of …

The British Society of Gastroenterology in collaboration with British Association for the Study
of the Liver has prepared this document. The aim of this guideline is to review and …

There is a universal agreement that the occurrence of clinical complications, such as ascites,
hepatic encephalopathy, gastrointestinal bleeding, and jaundice mark the transition from the …

The human gut microbiome has emerged as a major player in human health and disease.
The liver, as the first organ to encounter microbial products that cross the gut epithelial …

The pathophysiological background of decompensated cirrhosis is characterised by a
systemic proinflammatory and pro-oxidant milieu that plays a major role in the development …