[HTML][HTML] Machine learning applications in microbial ecology, human microbiome studies, and environmental monitoring
RB Ghannam, SM Techtmann - Computational and Structural …, 2021 - Elsevier
Advances in nucleic acid sequencing technology have enabled expansion of our ability to
profile microbial diversity. These large datasets of taxonomic and functional diversity are key …
profile microbial diversity. These large datasets of taxonomic and functional diversity are key …
Converting nanotoxicity data to information using artificial intelligence and simulation
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …
However, data is not equal to information. The question is how to extract critical information …
Molecular basis of astrocyte diversity and morphology across the CNS in health and disease
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …
[HTML][HTML] Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy
SARS-CoV-2 messenger RNA vaccination in healthy individuals generates immune
protection against COVID-19. However, little is known about SARS-CoV-2 mRNA vaccine …
protection against COVID-19. However, little is known about SARS-CoV-2 mRNA vaccine …
Interpretable machine learning: Fundamental principles and 10 grand challenges
Interpretability in machine learning (ML) is crucial for high stakes decisions and
troubleshooting. In this work, we provide fundamental principles for interpretable ML, and …
troubleshooting. In this work, we provide fundamental principles for interpretable ML, and …
[HTML][HTML] CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
B Kruse, AC Buzzai, N Shridhar, AD Braun, S Gellert… - Nature, 2023 - nature.com
Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to
directly recognize and kill tumour cells,–. These strategies are limited by the emergence of …
directly recognize and kill tumour cells,–. These strategies are limited by the emergence of …
[HTML][HTML] Enhanced safety and efficacy of protease-regulated CAR-T cell receptors
Regulatable CAR platforms could circumvent toxicities associated with CAR-T therapy, but
existing systems have shortcomings including leakiness and attenuated activity. Here, we …
existing systems have shortcomings including leakiness and attenuated activity. Here, we …
[HTML][HTML] Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells
I Schulien, J Kemming, V Oberhardt, K Wild… - Nature medicine, 2021 - nature.com
Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …
Understanding how dimension reduction tools work: an empirical approach to deciphering t-SNE, UMAP, TriMAP, and PaCMAP for data visualization
Dimension reduction (DR) techniques such as t-SNE, UMAP, and TriMap have
demonstrated impressive visualization performance on many real-world datasets. One …
demonstrated impressive visualization performance on many real-world datasets. One …
[HTML][HTML] Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation
Age is a non-modifiable risk factor for the inflammation that underlies age-associated
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …