Introduction: Many new drug substances have low aqueous solubility which can cause poor
bioavailability after oral administration. The application of solid dispersions is a useful …

Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-
soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the …

Solubility is an important determinant in drug liberation and hence drug absorption, which
plays a key role in oral bioavailability of formulations. The dissolution rate of a drug directly …

Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. It
was suggested that albendazole (ABZ) is a powerful inhibitor of several carcinoma types …

The study investigated chitosan coated nanostructured lipid carriers (NLCs) for oral delivery
of albendazole in treatment of trichinellosis. NLCs comprised precirol and oleic acid with …

Helminthic infections are produced by different types of worms and affect millions of people
worldwide. Benzimidazole compounds such as ricobendazole (RBZ) are widely used to treat …

Albendazole (ABZ) is a broad-spectrum antiparasitic drug used in the treatment of human or
animal infections. Although ABZ has shown a high efficacy for repeated doses in …

This study investigates the potential of poloxamers as solid dispersions (SDs) carriers in
improving the dissolution rate of a poorly soluble drug, carbamazepine (CBZ). Solid …

This study aimed at systematically investigating the role of distributive comb mixing element
(GLC) and neutral dispersive mixing kneading block element (K90) on the structure and …

Benznidazole (BZL), the first line drug for Chagas disease treatment, presents a low
solubility, limiting the possibilities for its formulation. In this work, solid dispersions'(SDs) …