Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is
active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism …

We are approaching the 100th anniversary of Otto Warburg's first description of the
metabolic phenotype bearing his name—a propensity for tumours to metabolize glucose …

A long-standing question in cancer biology has been why oxygenated tumors ferment the
majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a …

The mitochondrial electron transport chain (ETC) is necessary for tumour growth,,,,–and its
inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies …

Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …

Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Transformed cells adapt metabolism to support tumor initiation and progression. Specific
metabolic activities can participate directly in the process of transformation or support the …