Inflammatory biomarkers of low back pain and disc degeneration: a review

AN Khan, HE Jacobsen, J Khan… - Annals of the new …, 2017 - Wiley Online Library
Biomarkers are biological characteristics that can be used to indicate health or disease. This
paper reviews studies on biomarkers of low back pain (LBP) in human subjects. LBP is the …

Application of stereolithography based 3D printing technology in investment casting

M Mukhtarkhanov, A Perveen, D Talamona - Micromachines, 2020 - mdpi.com
Advanced methods for manufacturing high quality parts should be used to ensure the
production of competitive products for the world market. Investment casting (IC) is a process …

Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases

KT Weber, DO Alipui, CP Sison, O Bloom… - Arthritis research & …, 2016 - Springer
Background Many intervertebral disc diseases cause low back pain (LBP). Proinflammatory
cytokines and matrix metalloproteinases (MMPs) participate in disc pathology. In this study …

Nonspecific low back pain: inflammatory profiles of patients with acute and chronic pain

JA Teodorczyk-Injeyan, JJ Triano… - The Clinical journal of …, 2019 - journals.lww.com
Background: The pathogenesis of low back pain (LBP) remains unclear. However, recent
studies suggest that the inflammatory response may be inherent in spinal pain. The purpose …

Cell therapy for the degenerating intervertebral disc

W Tong, Z Lu, L Qin, RL Mauck, HE Smith, LJ Smith… - Translational …, 2017 - Elsevier
Spinal conditions related to intervertebral disc (IVD) degeneration cost billions of dollars in
the US annually. Despite the prevalence and soaring cost, there is no specific treatment that …

Mast cell-intervertebral disc cell interactions regulate inflammation, catabolism and angiogenesis in discogenic back pain

MG Wiet, A Piscioneri, SN Khan, MN Ballinger… - Scientific reports, 2017 - nature.com
Low back pain (LBP) is a widespread debilitating disorder of significant socio-economic
importance and intervertebral disc (IVD) degeneration has been implicated in its …

Resveratrol inhibition of the WNT/β-catenin pathway following discogenic low back pain

T Genovese, D Impellizzeri, R D'Amico… - International Journal of …, 2022 - mdpi.com
Low back pain (LBP) management is an important clinical issue. Inadequate LBP control
has consequences on the mental and physical health of patients. Thus, acquiring new …

In search of biomarkers for low back pain: can traction therapy effectiveness be prognosed by surface electromyography or blood parameters?

M Ratajczak, M Waszak, E Śliwicka, M Wendt… - Frontiers in …, 2023 - frontiersin.org
Background: Lumbar traction therapy is a common method to reduce low back pain (LBP)
but is not always effective. The search for biomarkers that would prognose the effectiveness …

[HTML][HTML] Severity of intervertebral disc herniation regulates cytokine and chemokine levels in patients with chronic radicular back pain

HE Jacobsen, AN Khan, ME Levine, CG Filippi… - Osteoarthritis and …, 2020 - Elsevier
Objective The contributions of intervertebral disc disease and subject-specific covariates to
systemic inflammation in low back pain are unknown. We examined the effects of …

Injectable hyaluronic acid down-regulates interferon signaling molecules, IGFBP3 and IFIT3 in the bovine intervertebral disc

Z Kazezian, Z Li, M Alini, S Grad, A Pandit - Acta biomaterialia, 2017 - Elsevier
Low back pain which is a major cause of disability for people aged between 20 and 50 years
imposes a serious socio-economic burden. The current focus of regenerative medicine is on …