Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …

Despite their key regulatory role and therapeutic potency, the molecular signatures of
interactions between T cells and antigen-presenting myeloid cells within the tumor …

Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals,–, many others experience milder …

Cellular functions are strongly dependent on surrounding cells and environmental factors.
Current technologies are limited in their ability to characterize the spatial location and gene …

Acute viral infections are characterized by rapid increases in viral load, leading to cellular
damage and the resulting induction of complex innate and adaptive antiviral immune …

Alongside vaccines, antiviral drugs are becoming an integral part of our response to the
SARS‐CoV‐2 pandemic. Nirmatrelvir—an orally available inhibitor of the 3‐chymotrypsin …

During chronic viral infection, the inflammatory function of CD4 T-cells becomes gradually
attenuated. Concurrently, Th1 cells progressively acquire the capacity to secrete the …

We have previously shown that healthy older adults exhibit reduced cutaneous immune
responses during a varicella zoster virus (VZV) antigen challenge that correlated with a …

Identifying the molecular mechanisms that promote optimal immune responses to
coronavirus disease 2019 (COVID-19) vaccination is critical for future rational vaccine …