T cells in health and disease

L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders

NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Crosstalk of inflammatory cytokines within the breast tumor microenvironment

O Habanjar, R Bingula, C Decombat… - International journal of …, 2023 - mdpi.com
Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

NK cell metabolism and tumor microenvironment

I Terrén, A Orrantia, J Vitallé… - Frontiers in …, 2019 - frontiersin.org
Natural Killer (NK) cells are characterized by their potential to kill tumor cells by different
means without previous sensitization and have, therefore, become a valuable tool in cancer …

High-dimensional single-cell analysis of human natural killer cell heterogeneity

L Rebuffet, JE Melsen, B Escalière… - Nature …, 2024 - nature.com
Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to
microbes and tumors. Historically, their classification hinged on a limited array of surface …

NK cell-based immune checkpoint inhibition

M Khan, S Arooj, H Wang - Frontiers in immunology, 2020 - frontiersin.org
Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …

Allogeneic natural killer cell therapy

MM Berrien-Elliott, MT Jacobs, TA Fehniger - Blood, 2023 - ashpublications.org
Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …

A pH‐Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect

R Cheng, L Jiang, H Gao, Z Liu, E Mäkilä… - Advanced …, 2022 - Wiley Online Library
As a result of the deficient tumor‐specific antigens, potential off‐target effect, and influence
of protein corona, metal–organic framework nanoparticles have inadequate accumulation in …

Tumors evade immune cytotoxicity by altering the surface topology of NK cells

X Zheng, Z Hou, Y Qian, Y Zhang, Q Cui, X Wang… - Nature …, 2023 - nature.com
The highly variable response rates to immunotherapies underscore our limited knowledge
about how tumors can manipulate immune cells. Here the membrane topology of natural …