Osteoarthritis (OA) is a chronic degenerative disease featured by cartilage erosion and
inflammation. Luteolin, a member of the flavonoid family, has been shown to exert anti …

TIMM13 (translocase of inner mitochondrial membrane 13) located at the mitochondrial
intermembrane space is vital for the integrity and function of mitochondria. We found that the …

Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via
mechanisms that are believed to mimic the pathways associated with brain ischemia. In SH …

Abstract Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can
activate Nrf2 signaling by alkylating Keap1's cysteine residues. Here, we tested the potential …

Abstract Sphingosine kinases (SphK), including SphK1 and SphK2, are important enzymes
promoting progression of prostate cancer. SKI-178 is a novel and highly potent SphK1/2 …

Objective Osteoarthritis (OA), widely seen in the elderly, is featured by cartilage degradation,
subchondral bone remolding, and synovium inflammation. Currently, there is no cure for OA …

IGF2BP1 overexpression promotes hepatocellular carcinoma (HCC) progression. Long non-
coding RNA LIN28B-AS1 directly binds to IGF2BP1. In the present study, LIN28B-AS1 and …

A1874 is a novel BRD4-degrading proteolysis targeting chimera (PROTAC). In primary
colon cancer cells and established HCT116 cells, A1874 potently inhibited cell viability …

An ultra-large structure-based virtual screening has discovered iKeap1 as a direct Keap1
inhibitor that can efficiently activate Nrf2 signaling. We here tested its potential effect against …

Activation of adenosine monophosphate-activated protein kinase (AMPK) is able to produce
significant anti-non-small cell lung cancer (NSCLC) cell activity. ASP4132 is an orally active …