Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

The interplay between cellular stress and immune response can be variable and sometimes
contradictory. The mechanisms by which stress-activated pathways regulate the …

Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …

Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent
immune regulators of macrophages in response to inflammatory stimuli or lipid overloading …

Cholesterol has gained tremendous attention as an essential lipid in the life cycle of virtually
all viruses. These seem to have developed manifold strategies to modulate the cholesterol …

Macrophages exert potent effector functions against invading microorganisms but constitute,
paradoxically, a preferential niche for many bacterial strains to replicate. Using a model of …

Purpose Cardiovascular disease (CVD) is the leading cause of death, globally, and its
prevalence is only expected to rise due to the increasing incidence of co-morbidities such as …

Hepatic macrophages, the key cellular components of the liver, emerge as essential players
in liver inflammation, tissue repair and subsequent fibrosis, as well as tumorigenesis …

Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its
widespread clinical use. Rosi functions as a high-affinity ligand for peroxisome proliferator …

Cholesterol is essential for brain function and structure, however altered cholesterol
metabolism and transport are hallmarks of multiple neurodegenerative conditions, including …