[HTML][HTML] DNA methylation in human diseases

Z Jin, Y Liu - Genes & diseases, 2018 - Elsevier
Even though the importance of epigenetics was first recognized in light of its role in tissue
development, an increasing amount of evidence has shown that it also plays an important …

Statistical and integrative system-level analysis of DNA methylation data

AE Teschendorff, CL Relton - Nature Reviews Genetics, 2018 - nature.com
Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …

Children born small for gestational age: differential diagnosis, molecular genetic evaluation, and implications

MJJ Finken, M van der Steen, CCJ Smeets… - Endocrine …, 2018 - academic.oup.com
Children born small for gestational age (SGA), defined as a birth weight and/or length
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …

[HTML][HTML] The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis

S Lapehn, AG Paquette - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review The developmental origins of health and disease (DOHaD)
hypothesis posits that the perinatal environment can impact fetal and later life health. The …

[HTML][HTML] Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature …

GM Power, E Sanderson, P Pagoni, A Fraser… - European Journal of …, 2023 - Springer
Diseases diagnosed in adulthood may have antecedents throughout (including prenatal)
life. Gaining a better understanding of how exposures at different stages in the lifecourse …

[HTML][HTML] Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated …

S Rauschert, PE Melton, G Burdge, JM Craig… - Frontiers in …, 2019 - frontiersin.org
Background: Several studies have shown effects of current and maternal smoking during
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …

[HTML][HTML] Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual …

EM Philips, S Santos, L Trasande… - PLoS …, 2020 - journals.plos.org
Background Fetal smoke exposure is a common and key avoidable risk factor for birth
complications and seems to influence later risk of overweight. It is unclear whether this …

A systematic review of smoking-related epigenetic alterations

G Kaur, R Begum, S Thota, S Batra - Archives of Toxicology, 2019 - Springer
The aim of this study is to provide a systematic review of the known epigenetic alterations
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …

[HTML][HTML] Epigenetic alterations of maternal tobacco smoking during pregnancy: a narrative review

A Nakamura, O François, J Lepeule - International Journal of …, 2021 - mdpi.com
In utero exposure to maternal tobacco smoking is the leading cause of birth complications in
addition to being associated with later impairment in child's development. Epigenetic …

Mediation by placental DNA methylation of the association of prenatal maternal smoking and birth weight

A Cardenas, SM Lutz, TM Everson… - American Journal of …, 2019 - academic.oup.com
Prenatal maternal smoking is a risk factor for lower birth weight. We performed epigenome-
wide association analyses of placental DNA methylation (DNAm) at 720,077 cytosine …