Claudin barriers on the brink: how conflicting tissue and cellular priorities drive IBD pathogenesis
CT Capaldo - International Journal of Molecular Sciences, 2023 - mdpi.com
Inflammatory bowel diseases (IBDs) are characterized by acute or chronic recurring
inflammation of the intestinal mucosa, often with increasing severity over time. Life-long …
inflammation of the intestinal mucosa, often with increasing severity over time. Life-long …
Breaking the gingival barrier in periodontitis
L Vitkov, J Singh, C Schauer, B Minnich… - International Journal of …, 2023 - mdpi.com
The break of the epithelial barrier of gingiva has been a subject of minor interest, albeit
playing a key role in periodontal pathology, transitory bacteraemia, and subsequent …
playing a key role in periodontal pathology, transitory bacteraemia, and subsequent …
Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex
TP Nguyen, T Otani, M Tsutsumi, N Kinoshita… - Journal of Cell …, 2024 - rupress.org
Epithelia must be able to resist mechanical force to preserve tissue integrity. While
intercellular junctions are known to be important for the mechanical resistance of epithelia …
intercellular junctions are known to be important for the mechanical resistance of epithelia …
ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of septate junction integrity in Drosophila epithelial cells
TE de Bournonville, MK Jaglarz, E Durel, R Le Borgne - Elife, 2024 - elifesciences.org
Barrier functions of proliferative epithelia are constantly challenged by mechanical and
chemical constraints. How epithelia respond to and cope with disturbances of barrier …
chemical constraints. How epithelia respond to and cope with disturbances of barrier …
ZnUMBA–a live imaging method to detect local barrier breaches
T Higashi, RE Stephenson, C Schwayer… - Journal of Cell …, 2023 - journals.biologists.com
Epithelial barrier function is commonly analyzed using transepithelial electrical resistance,
which measures ion flux across a monolayer, or by adding traceable macromolecules and …
which measures ion flux across a monolayer, or by adding traceable macromolecules and …
Kidney-specific membrane-bound serine proteases CAP1/Prss8 and CAP3/St14 affect ENaC subunit abundances but not its activity
E Ehret, S Stroh, M Auberson, F Ino, Y Jäger… - Cells, 2023 - mdpi.com
The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating
proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC …
proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC …
Tight-junction strand networks and tightness of the epithelial barrier
AC Saito, T Higashi, H Chiba - Microscopy, 2023 - academic.oup.com
Tight junctions (TJs) are cell–cell junction structures critical for controlling paracellular
permeability. On freeze-fracture replica electron microscopy, they appear as a continuous …
permeability. On freeze-fracture replica electron microscopy, they appear as a continuous …
Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM
R Szabo, M Kawaguchi, H Kataoka… - Development, 2023 - journals.biologists.com
Congenital tufting enteropathy (CTE) is a life-threatening intestinal disorder resulting from
loss-of-function mutations in EPCAM and SPINT2. Mice deficient in Spint2, encoding the …
loss-of-function mutations in EPCAM and SPINT2. Mice deficient in Spint2, encoding the …
[HTML][HTML] Claudin-4 polymerizes after a small extracellular claudin-3-like substitution
RE van der Veen, J Piontek, M Bieck, A Saiti… - Journal of Biological …, 2024 - Elsevier
Tight junctions play a pivotal role in the functional integrity of the human body by forming
barriers that compartmentalize tissues and protect the body from external threats. Essential …
barriers that compartmentalize tissues and protect the body from external threats. Essential …
[HTML][HTML] Damage control of epithelial barrier function in dynamic environments
T Higashi, AC Saito, H Chiba - European Journal of Cell Biology, 2024 - Elsevier
Epithelial tissues cover the surfaces and lumens of the internal organs of multicellular
animals and crucially contribute to internal environment homeostasis by delineating distinct …
animals and crucially contribute to internal environment homeostasis by delineating distinct …