Inflammatory bowel diseases (IBDs) are characterized by acute or chronic recurring
inflammation of the intestinal mucosa, often with increasing severity over time. Life-long …

The break of the epithelial barrier of gingiva has been a subject of minor interest, albeit
playing a key role in periodontal pathology, transitory bacteraemia, and subsequent …

Epithelia must be able to resist mechanical force to preserve tissue integrity. While
intercellular junctions are known to be important for the mechanical resistance of epithelia …

Barrier functions of proliferative epithelia are constantly challenged by mechanical and
chemical constraints. How epithelia respond to and cope with disturbances of barrier …

Epithelial barrier function is commonly analyzed using transepithelial electrical resistance,
which measures ion flux across a monolayer, or by adding traceable macromolecules and …

The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating
proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC …

Tight junctions (TJs) are cell–cell junction structures critical for controlling paracellular
permeability. On freeze-fracture replica electron microscopy, they appear as a continuous …

Congenital tufting enteropathy (CTE) is a life-threatening intestinal disorder resulting from
loss-of-function mutations in EPCAM and SPINT2. Mice deficient in Spint2, encoding the …

Tight junctions play a pivotal role in the functional integrity of the human body by forming
barriers that compartmentalize tissues and protect the body from external threats. Essential …

Epithelial tissues cover the surfaces and lumens of the internal organs of multicellular
animals and crucially contribute to internal environment homeostasis by delineating distinct …