La cocaína es la droga responsable de más muertes en España. A pesar de una
disminución del consumo en los últimos años, la prevalencia continúa siendo alta y es …

Importance Adult attention-deficit/hyperactivity disorder (ADHD) is prevalent but often
unrecognized, in part because it tends to co-occur with other disorders such as substance …

Efficacious pharmacotherapies for the treatment of substance use disorders need to be
expanded and improved. Non-neuronal cells, particularly astrocytes and microglia, have …

Background Ascertaining agreement between DSM-IV and DSM-5 is important to determine
the applicability of treatments for DSM-IV conditions to persons diagnosed according to the …

The dopamine system is a primary treatment target for cocaine dependence (CD), but
research on dopaminergic abnormalities (eg, D 2 receptor system deficiencies) has so far …

The treatment for cocaine use constitutes a clinical challenge because of the lack of
appropriate therapies and the high rate of relapse. Recent evidence indicates that the …

Brain imaging studies using positron emission tomography (PET) have shown that long-term
cocaine use is associated with lower levels of dopamine (DA) D2/D3 receptors (D2/D3R); …

Background Impurities in commonly used illicit drugs raise concerns for unwitting consumers
when pharmacologically active adulterants, especially new psychoactive substances (NPS) …

The cocaine vaccine dAd5GNE is comprised of a disrupted serotype 5 adenovirus gene
therapy vector covalently conjugated to the cocaine analog GNE. The vaccine evokes a high …

Preclinical studies implicate a role for α 1-noradrenergic receptors in the effects of
psychostimulants, including 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”). The …