In cancerous cells, significant changes occur in the activity of signaling pathways affecting a
wide range of cellular activities ranging from growth and proliferation to apoptosis …

Cancer cells must maintain metabolic homeostasis under a wide range of conditions and
meet their own energy needs in order to survive and reproduce. In addition to glycolysis …

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its
prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 …

Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

Background Altered lipid metabolism is closely related to the occurrence and development
of hepatocellular carcinoma (HCC). Carnitine palmitoyltransferase 1C (CPT1C) is a member …

Background Prostate cancer is characterized by aberrant lipid metabolism, including
elevated fatty acid oxidation. Carnitine palmitoyltransferase 1B (CPT1B) catalyzes the rate …

Rationale: MicroRNAs are known to influence the development of a variety of cancers.
Previous studies revealed that miR-1291 has antiproliferative functions in cancer cells …

There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis,
prognosis, and treatment of different tumor types. Described as a prognostic marker for many …

Lipid metabolism involves multiple biological processes. As one of the most important lipid
metabolic pathways, fatty acid oxidation (FAO) and its key rate-limiting enzyme, the carnitine …

Hepatocellular carcinoma (HCC) has developed into one of the most lethal, aggressive, and
malignant cancers worldwide. Although HCC treatment has improved in recent years, the …