The recent outbreak of coronavirus disease 2019 (COVID‐19), caused by the Severe Acute
Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) has resulted in a world‐wide …

Despite the progress made in the clinical management of sepsis, sepsis morbidity and
mortality rates remain high. The inflammatory pathogenesis and organ injury leading to …

During the systemic inflammatory response of severe sepsis, neutrophils accumulate in the
liver microcirculation, but their functional significance is largely unknown. We show that …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Heat stroke is a life‐threatening condition clinically diagnosed as a severe elevation in body
temperature with central nervous system dysfunction that often includes combativeness …

Organ dysfunction or overt failure is a commonplace event in the critically ill affecting up to
70% of patients during their stay in the ICU. The outcome depends on the resolution of …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

During sepsis, the liver plays a key role. It is implicated in the host response, participating in
the clearance of the infectious agents/products. Sepsis also induces liver damage through …

Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and
proliferation. Many studies have shown that Src plays multiple roles in macrophage …