Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon
binding to target proteins transduces signals encoded by global or subcellular-specific …

Abstract In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …

The importance of Ca2+ signalling in key events of cancer cell function and tumour
progression, such as proliferation, migration, invasion and survival, has recently begun to be …

Medulloblastoma is the most common malignant brain cancer in pediatrics consisting of four
molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and Group …

Gliomas are the most common form of malignant primary brain tumors in humans and
second most common in dogs, occurring with similar frequencies in both species. Dogs are …

Triple-negative breast cancers (TNBC) tend to become invasive and metastatic at early
stages in their development. Despite some treatment successes in early-stage localized …

The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1,
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …

Medulloblastoma is the most common malignant brain tumor of childhood. Although there is
now long-term survival or cure for the majority of children, the survivors bear a significant …

Abstract The Rac inhibitor EHop-016 was developed as a compound with the potential to
inhibit cancer metastasis. Inhibition of the first step of metastasis, migration, is an important …

AKT and its substrate BAD have been shown to promote prostate cancer cell survival.
Agonists, such as carbachol, and hormones that increase intracellular calcium concentration …