The role of calmodulin in tumor cell migration, invasiveness, and metastasis
A Villalobo, MW Berchtold - International Journal of Molecular Sciences, 2020 - mdpi.com
Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon
binding to target proteins transduces signals encoded by global or subcellular-specific …
binding to target proteins transduces signals encoded by global or subcellular-specific …
Regulation and role of CAMKK2 in prostate cancer
TL Pulliam, P Goli, D Awad, C Lin… - Nature Reviews …, 2022 - nature.com
Abstract In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …
The multi-functional calcium/calmodulin stimulated protein kinase (CaMK) family: emerging targets for anti-cancer therapeutic intervention
JS Brzozowski, KA Skelding - Pharmaceuticals, 2019 - mdpi.com
The importance of Ca2+ signalling in key events of cancer cell function and tumour
progression, such as proliferation, migration, invasion and survival, has recently begun to be …
progression, such as proliferation, migration, invasion and survival, has recently begun to be …
Molecular determinants of medulloblastoma metastasis and leptomeningeal dissemination
M Li, Y Deng, W Zhang - Molecular Cancer Research, 2021 - AACR
Medulloblastoma is the most common malignant brain cancer in pediatrics consisting of four
molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and Group …
molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and Group …
Utilizing the dog genome in the search for novel candidate genes involved in glioma development—genome wide association mapping followed by targeted massive …
K Truvé, P Dickinson, A Xiong, D York… - PLoS …, 2016 - journals.plos.org
Gliomas are the most common form of malignant primary brain tumors in humans and
second most common in dogs, occurring with similar frequencies in both species. Dogs are …
second most common in dogs, occurring with similar frequencies in both species. Dogs are …
Targeting CaMKK2 inhibits actin cytoskeletal assembly to suppress cancer metastasis
D Mukherjee, RA Previs, C Haines, M Al Abo, PK Juras… - Cancer research, 2023 - AACR
Triple-negative breast cancers (TNBC) tend to become invasive and metastatic at early
stages in their development. Despite some treatment successes in early-stage localized …
stages in their development. Despite some treatment successes in early-stage localized …
In depth analysis of kinase cross screening data to identify CAMKK2 inhibitory scaffolds
SN O'Byrne, JW Scott, JR Pilotte, AS Santiago… - Molecules, 2020 - mdpi.com
The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1,
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …
Medulloblastoma: recurrence and metastasis
D Aref, S Croul - CNS oncology, 2013 - Taylor & Francis
Medulloblastoma is the most common malignant brain tumor of childhood. Although there is
now long-term survival or cure for the majority of children, the survivors bear a significant …
now long-term survival or cure for the majority of children, the survivors bear a significant …
Development of EHop-016: a small molecule inhibitor of Rac
S Dharmawardhane, E Hernandez, C Vlaar - The enzymes, 2013 - Elsevier
Abstract The Rac inhibitor EHop-016 was developed as a compound with the potential to
inhibit cancer metastasis. Inhibition of the first step of metastasis, migration, is an important …
inhibit cancer metastasis. Inhibition of the first step of metastasis, migration, is an important …
CaM kinase control of AKT and LNCaP cell survival
JM Schmitt, S Smith, B Hart… - Journal of cellular …, 2012 - Wiley Online Library
AKT and its substrate BAD have been shown to promote prostate cancer cell survival.
Agonists, such as carbachol, and hormones that increase intracellular calcium concentration …
Agonists, such as carbachol, and hormones that increase intracellular calcium concentration …