Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

L-Asparaginase (ASNase) is a vital component of the first line treatment of acute
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …

Abstract l-asparaginase (l-asparagine amino hydrolase, EC 3.5. 1.1) is an enzyme clinically
accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma …

L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully
used in the treatment of acute lymphoblastic leukemia. L-asparaginase toxicity is either …

Abstract L-Asparaginase (L-ASNase, EC 3.5. 1.1), an antitumor drug for acute lymphoblastic
leukemia (ALL) therapy, is widely used in the clinical field. Similarly, L-ASNase is also a …

L-asparaginases (EC 3.5. 1.1) are a family of enzymes that catalyze the hydrolysis of L-
asparagine to L-aspartic acid and ammonia. These proteins with different biochemical …

L-asparaginase, an anti-leukaemic drug that has been approved for clinical use for many
years in the treatment of childhood Acute Lymphoblastic Leukaemia (ALL), is obtained from …

Background L-asparaginase (ASNase) has played a key role in the management of acute
lymphoblastic leukaemia (ALL). As an amidohydrolase, it catalyzes the hydrolysis of L …

The optimal use of many biotherapeutics is restricted by Anti-drug antibodies (ADAs) and
hypersensitivity responses which can affect potency and ability to administer a treatment …

Over the past few years, there has been a surge in the industrial production of recombinant
enzymes from microorganisms due to their catalytic characteristics being highly efficient …