The emergence of Zika virus and its new clinical syndromes
TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …
threat because of its potential to generate explosive epidemics and ability to cause …
Zika virus infection as a cause of congenital brain abnormalities and Guillain–Barré syndrome: systematic review
Background The World Health Organization (WHO) stated in March 2016 that there was
scientific consensus that the mosquito-borne Zika virus was a cause of the neurological …
scientific consensus that the mosquito-borne Zika virus was a cause of the neurological …
The Brazilian Zika virus strain causes birth defects in experimental models
Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and
was first described in 1947 in Uganda following blood analyses of sentinel Rhesus …
was first described in 1947 in Uganda following blood analyses of sentinel Rhesus …
Zika virus infection during pregnancy in mice causes placental damage and fetal demise
JJ Miner, B Cao, J Govero, AM Smith, E Fernandez… - Cell, 2016 - cell.com
Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction,
spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental …
spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental …
Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy
The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …
Zika virus infection damages the testes in mice
J Govero, P Esakky, SM Scheaffer, E Fernandez… - Nature, 2016 - nature.com
Infection of pregnant women with Zika virus (ZIKV) can cause congenital malformations
including microcephaly, which has focused global attention on this emerging pathogen. In …
including microcephaly, which has focused global attention on this emerging pathogen. In …
Zika virus pathogenesis and tissue tropism
JJ Miner, MS Diamond - Cell host & microbe, 2017 - cell.com
Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental
studies had been published prior to 2016. The recent spread of ZIKV to countries in the …
studies had been published prior to 2016. The recent spread of ZIKV to countries in the …
Viral innate immune evasion and the pathogenesis of emerging RNA virus infections
T Nelemans, M Kikkert - Viruses, 2019 - mdpi.com
Positive-sense single-stranded RNA (+ ssRNA) viruses comprise many (re-) emerging
human pathogens that pose a public health problem. Our innate immune system and, in …
human pathogens that pose a public health problem. Our innate immune system and, in …
Zika virus targets human STAT2 to inhibit type I interferon signaling
The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as
emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome …
emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome …
Zika virus—reigniting the TORCH
CB Coyne, HM Lazear - Nature Reviews Microbiology, 2016 - nature.com
The recent association between Zika virus (ZIKV) infection during pregnancy and fetal
microcephaly has led to a renewed interest in the mechanisms by which vertically …
microcephaly has led to a renewed interest in the mechanisms by which vertically …