Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis

SO Tone, V Kocaba, M Böhm, A Wylegala… - Progress in Retinal and …, 2021 - Elsevier
Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal
endothelial dystrophy and the leading indication for corneal transplantation worldwide …

Predictors of receiving keratoplasty for Fuchs' endothelial corneal dystrophy among Medicare beneficiaries

NJ Heckenlaible, C Dun, C Prescott, AO Eghrari… - Ophthalmology, 2023 - Elsevier
Purpose To identify factors associated with receipt of endothelial keratoplasty (EK) and
penetrating keratoplasty (PK) in patients with Fuchs' endothelial corneal dystrophy (FECD) …

[HTML][HTML] The TCF4 trinucleotide repeat expansion of Fuchs' endothelial corneal dystrophy: implications for the anterior segment of the eye

J Hu, X Gong, ST Johnson, DR Corey… - … & visual science, 2023 - jov.arvojournals.org
Purpose: In the United States, 70% of Fuchs' endothelial corneal dystrophy (FECD) cases
are caused by an intronic trinucleotide repeat expansion in the TCF4 gene. CUG repeat …

Clinical phenotypes of Fuchs endothelial corneal dystrophy (FECD), disease progression, differential diagnosis, and medical therapy

B Seitz, T Hager - Current treatment options for Fuchs endothelial …, 2017 - Springer
The hallmark of Fuchs endothelial corneal dystrophy (FECD) is corneal “guttae”. However,
some eyes with cornea guttata will never progress to FECD! Thus, we should talk about …

Increased Risk of Glaucoma in Fuchs Endothelial Corneal Dystrophy Is Independent of TCF4 Trinucleotide Repeat Expansion

C Xing, S Schultis, V Bondar, X Gong, JT Whitson… - Cornea, 2022 - journals.lww.com
Purpose: The purpose of this study was to determine the prevalence of glaucoma and/or
ocular hypertension (G/OHTN) in patients with Fuchs endothelial corneal dystrophy (FECD) …

Genetic analysis of corneal dystrophies

S Siddiqui - 2016 - etheses.whiterose.ac.uk
Corneal disease is a major cause of global blindness accounting for around 2% of severe
visual impairment in the UK. Corneal dystrophies are a group of rare, bilateral conditions …

Genetic variant rs613872 in transcription factor 4 (TCF4) is not associated with primary open-angle glaucoma

AA Kondkar, TA Azad, T Sultan, EA Osman… - Eye, 2021 - nature.com
Transcription factors play a key role in transcriptional gene regulation in both physiological
and pathophysiological mechanisms of human diseases. Genes encoding transcription …

Fuchs endothelial corneal distrophy: a review

FF Silva - 2016 - repositorio.ul.pt
A distrofia de Fuchs é a distrofia endotelial da córnea mais comum e que resulta na perda
de visão. É caracterizada pela perda progressiva de células endoteliais, aumento da …

Fuchs Endothelial Corneal Distrophy: A Review

F Ferreira - 2016 - search.proquest.com
Fuchs endothelial corneal dystrophy is the most common corneal dystrophy and frequently
results in vision loss. Is characterized by progressive loss of corneal endothelial cells …