Background: Common variable immunodeficiency (CVID) is the most common clinically
significant primary immunodeficiency (PID) disorder characterized by variable clinical …

Introduction The process of immunoglobulin class switch recombination (CSR) occurs in
secondary lymphoid organs. This highly regulated process is essential for the development …

Background Primary antibody deficiencies (PAD) are characterized by a heterogeneous
clinical presentation and low prevalence, contributing to a median diagnostic delay of 3–10 …

Primary immunodeficiencies are heritable disorders of immune function. CD19 is a B cell co-
receptor important for B cell development, and CD19 deficiency is a known genetic risk …

Primary antibody deficiencies (PAD) are the most common subtype of primary
immunodeficiencies, characterized by increased susceptibility to infections and …

Common variable immunodeficiency (CVID) and immunoglobulin A deficiency (IgAD) are
the most prevalent primary immunodeficiency disorders. High rates of familial inheritance …

Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency is an
autosomal recessive primary immunodeficiency disease characterized by a CVID-like …

Background: Common variable immunodeficiency (CVID) is considered the most
symptomatic type of inborn errors of immunity in humans. Along with infectious …

ABSTRACT Objective: Primary immunodeficiencies (PIDs) consist of genetically
heterogeneous disorders. The spectrum can include infectious diseases, malignancy …

Mucosal antibodies maintain gut homeostasis by promoting spatial segregation between
host tissues and luminal microbes. Antibody-deficiency is the most common form of primary …