Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …
progression are being increasingly defined. The TRACERx Renal studies and others that …
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - Signal transduction and …, 2019 - nature.com
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
Renal cell carcinoma
Renal cell carcinoma (RCC) denotes cancer originated from the renal epithelium and
accounts for> 90% of cancers in the kidney. The disease encompasses> 10 histological and …
accounts for> 90% of cancers in the kidney. The disease encompasses> 10 histological and …
Intragenic DNA methylation prevents spurious transcription initiation
In mammals, DNA methylation occurs mainly at CpG dinucleotides. Methylation of the
promoter suppresses gene expression, but the functional role of gene-body DNA …
promoter suppresses gene expression, but the functional role of gene-body DNA …
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results
TA Yap, E Fontana, EK Lee, DR Spigel, M Højgaard… - Nature medicine, 2023 - nature.com
Predictive biomarkers of response are essential to effectively guide targeted cancer
treatment. Ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) have been shown …
treatment. Ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) have been shown …
The interplay of histone modifications–writers that read
T Zhang, S Cooper, N Brockdorff - EMBO reports, 2015 - embopress.org
Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
Metastasis as an evolutionary process
S Turajlic, C Swanton - Science, 2016 - science.org
Therapeutic advances in oncology have not fully translated to the treatment of metastatic
disease, which remains largely incurable. Metastatic subclones can emerge both early and …
disease, which remains largely incurable. Metastatic subclones can emerge both early and …
[HTML][HTML] Inhibiting WEE1 selectively kills histone H3K36me3-deficient cancers by dNTP starvation
Summary Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer
types, identifying it as an important therapeutic target. Here we identify a synthetic lethal …
types, identifying it as an important therapeutic target. Here we identify a synthetic lethal …
Choosing the right cell line for renal cell cancer research
KK Brodaczewska, C Szczylik, M Fiedorowicz, C Porta… - Molecular cancer, 2016 - Springer
Cell lines are still a tool of choice for many fields of biomedical research, including oncology.
Although cancer is a very complex disease, many discoveries have been made using …
Although cancer is a very complex disease, many discoveries have been made using …
Clustered mutation signatures reveal that error-prone DNA repair targets mutations to active genes
Many processes can cause the same nucleotide change in a genome, making the
identification of the mechanisms causing mutations a difficult challenge. Here, we show that …
identification of the mechanisms causing mutations a difficult challenge. Here, we show that …