Germline mutations in the BRCA genes are associated with a higher risk of carcinogenesis,
which is linked to an increased mutation rate and loss of the second unaffected BRCA allele …

Preneoplastic mammary tissues from human female BRCA1 mutation carriers, or Brca1-
mutant mice, display unexplained abnormalities in luminal differentiation. We now study the …

HOXA5 is a transcription factor and tumor suppressor that promotes differentiation of breast
epithelial cells and is frequently lost during malignant transformation. HOXA5 loss alone …

Background/purpose The combined contributions of oncogenes and tumor suppressor
genes toward carcinogenesis remain poorly understood. Elucidation of cancer gene …

Background BRCA1-associated breast cancer originates from luminal progenitor cells.
BRCA1 functions in multiple biological processes, including double-strand break repair …

Establishing a universally applicable protocol to assess the impact of BRCA1 variants of
uncertain significance (VUS) expression is a problem which has yet to be resolved despite …

BRCA‐related breast carcinoma can be prevented through prophylactic surgery and an
intensive follow‐up regimen. However, BRCA genetic tests cannot be routinely performed …

Protein-RNA interactions play an essential role in the regulation of transcription, translation,
and metabolism of cellular RNA. Here, we develop Reformer, a deep learning model that …

The polymorphic variants of BRCA1, which lead to amino acid substitutions, have a known
pathogenic role in breast cancer. The present study investigated in North Indian breast …

Female carriers of mutations in Breast cancer, early onset 1 (BRCA1) show an elevated risk
to develop breast cancers that resemble the primitive and proliferative cells of the mammary …