Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

While transcriptional control of innate immune gene expression is well characterized, almost
nothing is known about how pre-mRNA splicing decisions influence, or are influenced by …

Cryptococcus neoformans is not usually considered a cytotoxic fungal pathogen but there is
considerable evidence that this microbe can damage host cells and tissues. In this essay …

Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …

5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and
pathological conditions. AMPK is involved in energy metabolism, which is perturbed by …

The prevalence of fungal diseases is increasing on a global scale, ranging from acute to
systemic infections caused by commensal or pathogenic microorganisms, often associated …

Summary Histone 3 Lysine 4 (H3K4) demethylation is ubiquitous in organisms, however the
roles of H3K4 demethylase JARID1 (Jar1)/KDM5 in fungal development and pathogenesis …

For intracellular pathogens, host cells provide a replicative niche, but are also armed with
innate defense mechanisms to combat the intruder. Co-evolution of host and pathogens has …

The human body is composed not only of human cells but is occupied by bacteria, archaea,
fungi, and viruses; this ensemble of organisms (microbiota) and their expressed genes are …