The role of gut microbial β-glucuronidase in estrogen reactivation and breast cancer

Y Sui, J Wu, J Chen - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Over the past decade, the gut microbiota has received considerable attention for its
interactions with the host. Microbial β-glucuronidase generated by this community has …

Towards a mechanistic understanding of reciprocal drug–microbiome interactions

M Zimmermann, KR Patil, A Typas… - Molecular systems …, 2021 - embopress.org
Broad‐spectrum antibiotics target multiple gram‐positive and gram‐negative bacteria, and
can collaterally damage the gut microbiota. Yet, our knowledge of the extent of damage, the …

Personalized mapping of drug metabolism by the human gut microbiome

B Javdan, JG Lopez, P Chankhamjon, YCJ Lee, R Hull… - Cell, 2020 - cell.com
The human gut microbiome harbors hundreds of bacterial species with diverse biochemical
capabilities. Dozens of drugs have been shown to be metabolized by single isolates from …

Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation

JC Swarte, Y Li, S Hu, JR Björk, R Gacesa… - Science Translational …, 2022 - science.org
Organ transplantation is a life-saving treatment for patients with end-stage disease, but
survival rates after transplantation vary considerably. There is now increasing evidence that …

Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy

AP Bhatt, SJ Pellock, KA Biernat… - Proceedings of the …, 2020 - National Acad Sciences
Irinotecan treats a range of solid tumors, but its effectiveness is severely limited by
gastrointestinal (GI) tract toxicity caused by gut bacterial β-glucuronidase (GUS) enzymes …

Intrahepatic microbes govern liver immunity by programming NKT cells

JC Leinwand, B Paul, R Chen, F Xu… - The Journal of …, 2022 - Am Soc Clin Investig
The gut microbiome shapes local and systemic immunity. The liver is presumed to be a
protected sterile site. As such, a hepatic microbiome has not been examined. Here, we …

Gut microbiota in systemic lupus erythematosus: A fuse and a solution

Y Chen, J Lin, L Xiao, X Zhang, L Zhao, M Wang… - Journal of …, 2022 - Elsevier
Gut commensals help shape and mold host immune system and deeply influence human
health. The disease spectrum of mankind that gut microbiome may associate with is ever …

Integrating the gut microbiome and pharmacology

AA Verdegaal, AL Goodman - Science Translational Medicine, 2024 - science.org
The gut microbiome harbors trillions of organisms that contribute to human health and
disease. These bacteria can also affect the properties of medical drugs used to treat these …

[HTML][HTML] Psycho-pharmacomicrobiomics: a systematic review and meta-analysis

A Minichino, T Preston, JB Fanshawe, P Fusar-Poli… - Biological …, 2024 - Elsevier
Background Understanding the interactions between the gut microbiome and psychotropic
medications (psycho-pharmacomicrobiomics) could improve treatment stratification …

[HTML][HTML] Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences

P Gabarre, C Loens, Y Tamzali, B Barrou… - American Journal of …, 2022 - Elsevier
Our understanding of the involvement of the gut microbiota (GM) in human health has
expanded exponentially over the last few decades, particularly in the fields of metabolism …