The role of gut microbial β-glucuronidase in estrogen reactivation and breast cancer
Y Sui, J Wu, J Chen - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Over the past decade, the gut microbiota has received considerable attention for its
interactions with the host. Microbial β-glucuronidase generated by this community has …
interactions with the host. Microbial β-glucuronidase generated by this community has …
Towards a mechanistic understanding of reciprocal drug–microbiome interactions
Broad‐spectrum antibiotics target multiple gram‐positive and gram‐negative bacteria, and
can collaterally damage the gut microbiota. Yet, our knowledge of the extent of damage, the …
can collaterally damage the gut microbiota. Yet, our knowledge of the extent of damage, the …
Personalized mapping of drug metabolism by the human gut microbiome
The human gut microbiome harbors hundreds of bacterial species with diverse biochemical
capabilities. Dozens of drugs have been shown to be metabolized by single isolates from …
capabilities. Dozens of drugs have been shown to be metabolized by single isolates from …
Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation
Organ transplantation is a life-saving treatment for patients with end-stage disease, but
survival rates after transplantation vary considerably. There is now increasing evidence that …
survival rates after transplantation vary considerably. There is now increasing evidence that …
Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy
AP Bhatt, SJ Pellock, KA Biernat… - Proceedings of the …, 2020 - National Acad Sciences
Irinotecan treats a range of solid tumors, but its effectiveness is severely limited by
gastrointestinal (GI) tract toxicity caused by gut bacterial β-glucuronidase (GUS) enzymes …
gastrointestinal (GI) tract toxicity caused by gut bacterial β-glucuronidase (GUS) enzymes …
Intrahepatic microbes govern liver immunity by programming NKT cells
The gut microbiome shapes local and systemic immunity. The liver is presumed to be a
protected sterile site. As such, a hepatic microbiome has not been examined. Here, we …
protected sterile site. As such, a hepatic microbiome has not been examined. Here, we …
Gut microbiota in systemic lupus erythematosus: A fuse and a solution
Y Chen, J Lin, L Xiao, X Zhang, L Zhao, M Wang… - Journal of …, 2022 - Elsevier
Gut commensals help shape and mold host immune system and deeply influence human
health. The disease spectrum of mankind that gut microbiome may associate with is ever …
health. The disease spectrum of mankind that gut microbiome may associate with is ever …
Integrating the gut microbiome and pharmacology
AA Verdegaal, AL Goodman - Science Translational Medicine, 2024 - science.org
The gut microbiome harbors trillions of organisms that contribute to human health and
disease. These bacteria can also affect the properties of medical drugs used to treat these …
disease. These bacteria can also affect the properties of medical drugs used to treat these …
[HTML][HTML] Psycho-pharmacomicrobiomics: a systematic review and meta-analysis
Background Understanding the interactions between the gut microbiome and psychotropic
medications (psycho-pharmacomicrobiomics) could improve treatment stratification …
medications (psycho-pharmacomicrobiomics) could improve treatment stratification …
[HTML][HTML] Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences
P Gabarre, C Loens, Y Tamzali, B Barrou… - American Journal of …, 2022 - Elsevier
Our understanding of the involvement of the gut microbiota (GM) in human health has
expanded exponentially over the last few decades, particularly in the fields of metabolism …
expanded exponentially over the last few decades, particularly in the fields of metabolism …