[HTML][HTML] Inflammation as a central mechanism in Alzheimer's disease

JW Kinney, SM Bemiller, AS Murtishaw… - Alzheimer's & Dementia …, 2018 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

Astrocytes: role and functions in brain pathologies

R Siracusa, R Fusco, S Cuzzocrea - Frontiers in Pharmacology, 2019 - frontiersin.org
Astrocytes are a population of cells with distinctive morphological and functional
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …

Inflammation context in Alzheimer's disease, a relationship intricate to define

C Novoa, P Salazar, P Cisternas, C Gherardelli… - Biological Research, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

A review of cytokine-based pathophysiology of Long COVID symptoms

RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …

Role of Microglia and Astrocytes in Alzheimer's Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

G Di Benedetto, C Burgaletto, CM Bellanca, A Munafò… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex,
poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and …

Microglia and astrocytes in Alzheimer's disease: implications for therapy

M Fakhoury - Current neuropharmacology, 2018 - ingentaconnect.com
Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder
characterized by the progressive loss of neurons, which typically leads to severe …

Autophagy and Alzheimer's disease: from molecular mechanisms to therapeutic implications

MS Uddin, A Stachowiak, AA Mamun… - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

Neuroinflammation pathways: a general review

T Shabab, R Khanabdali… - International Journal …, 2017 - Taylor & Francis
Activated microglial cells play an important role in immune and inflammatory responses in
central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are …

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

Z Cai, MD Hussain, LJ Yan - International Journal of Neuroscience, 2014 - Taylor & Francis
Compelling evidence from basic molecular biology has demonstrated the dual roles of
microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are …

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

B Ajami, JL Bennett, C Krieger, KM McNagny… - Nature …, 2011 - nature.com
In multiple sclerosis and the experimental autoimmune encephalitis (EAE) mouse model,
two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory …