The mitosis-to-interphase transition involves dramatic cellular reorganization from a state
that supports chromosome segregation to a state that complies with all functions of an …

▪ Abstract Completion of the cell cycle requires the temporal and spatial coordination of
chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding …

The ability of cells to make exact replicas of themselves is central to the life and
development of complex organisms. Initial insights into the question of how cells divide …

In budding yeast, the phosphatase Cdc14, a key regulator of exit from mitosis, is released
from its inhibitor Cfi1/Net1 in the nucleolus during anaphase. A signaling cascade, known as …

Cytokinesis is a temporally and spatially regulated process through which the cellular
constituents of the mother cell are partitioned into two daughter cells, permitting an increase …

After anaphase, the high mitotic cyclin-dependent kinase (Cdk) activity is downregulated to
promote exit from mitosis. To this end, in the budding yeast S. cerevisiae, the Cdk …

Cytokinesis is the final event of the cell division cycle, and its completion results in
irreversible partition of a mother cell into two daughter cells. Cytokinesis was one of the first …

Centrosomes, spindle pole bodies, and related structures in other organisms are a
morphologically diverse group of organelles that share a common ability to nucleate and …

CDC14 was originally identified by L. Hartwell in his famous screen for genes that regulate
the budding yeast cell cycle. Subsequent work showed that Cdc14 belongs to a family of …

We show that human Cdc14A phosphatase interacts with interphase centrosomes, and that
this interaction is independent of microtubules and Cdc14A phosphatase activity, but …