Mitochondria as a cellular hub in infection and inflammation
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …
dynamic networks where they adapt energy production based on the cell's needs. They are …
Pathology and pathogenesis of Chagas heart disease
KM Bonney, DJ Luthringer, SA Kim… - Annual Review of …, 2019 - annualreviews.org
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
As spaceflight becomes more common with commercial crews, blood-based measures of
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease
Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …
disease and a cause of significant morbidity and mortality. No longer confined to endemic …
ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart
The activation of macrophage respiratory burst in response to infection with Trypanosoma
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …
[HTML][HTML] Immunity and vaccine development efforts against Trypanosoma cruzi
Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …
critical lack of methods for prevention of infection or treatment of acute infection and chronic …
Selenium and selenoproteins in prostanoid metabolism and immunity
Selenium (Se) is an essential trace element that functions in the form of the 21st amino acid,
selenocysteine (Sec) in a defined set of proteins. Se deficiency is associated with …
selenocysteine (Sec) in a defined set of proteins. Se deficiency is associated with …
Perspectives on Trypanosoma cruzi–induced heart disease (Chagas disease)
HB Tanowitz, FS Machado, LA Jelicks, J Shirani… - Progress in …, 2009 - Elsevier
Chagas disease is caused by the parasite Trypanosoma cruzi. It is a common cause of heart
disease in endemic areas of Latin America. The year 2009 marks the 100th anniversary of …
disease in endemic areas of Latin America. The year 2009 marks the 100th anniversary of …
SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart …
Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory
stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and …
stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and …
Sirtuin control of mitochondrial dysfunction, oxidative stress, and inflammation in chagas disease models
Trypanosoma cruzi is a digenetic parasite that requires triatomines and mammalian host to
complete its life cycle. T. cruzi replication in mammalian host induces immune-mediated …
complete its life cycle. T. cruzi replication in mammalian host induces immune-mediated …