Antiplasmodial natural products: an update

N Tajuddeen, FR Van Heerden - Malaria journal, 2019 - Springer
Background Malaria remains a significant public health challenge in regions of the world
where it is endemic. An unprecedented decline in malaria incidences was recorded during …

Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis

Y Liu, SX Jing, SH Luo, SH Li - Natural product reports, 2019 - pubs.rsc.org
Covering: 1960s to end of August 2018 Plant glandular trichomes (GTs) are adaptive
structures that are well known as “phytochemical factories” due to their impressive capacity …

Host plant forensics and olfactory-based detection in Afro-tropical mosquito disease vectors

VO Nyasembe, DP Tchouassi, CWW Pirk… - PLoS neglected …, 2018 - journals.plos.org
The global spread of vector-borne diseases remains a worrying public health threat, raising
the need for development of new combat strategies for vector control. Knowledge of vector …

Future antimalarials from Artemisia? A rationale for natural product mining against drug-refractory Plasmodium stages

A Maciuk, D Mazier, R Duval - Natural product reports, 2023 - pubs.rsc.org
Covering: up to 2023 Infusions of the plants Artemisia annua and A. afra are gaining broad
popularity to prevent or treat malaria. There is an urgent need to address this controversial …

The distinctive bionomics of Aedes aegypti populations in Africa

DP Tchouassi, SB Agha, J Villinger, R Sang… - Current Opinion in Insect …, 2022 - Elsevier
Aedes aegypti is the primary vector of dengue, chikungunya, and Zika viruses of medical
importance. Behavioral and biological attributes contribute to its vectorial capacity. The …

Terpenoids as emerging therapeutic agents: Cellular targets and mechanisms of action against protozoan parasites

MB Isah, N Tajuddeen, MI Umar, ZA Alhafiz… - Studies in natural …, 2018 - Elsevier
Terpenoids are the largest and structurally most diverse group of secondary metabolites
derived from natural sources. Empirical evidence from several bioassays points to the …

Chapter 7: Behavioural ecology of plant-mosquito relations

WA Foster - Sensory ecology of disease vectors, 2022 - wageningenacademic.com
This document, in two parts, evaluates the behavioural aspects of plants as a food source for
mosquitoes. First is a summary of the established basics of mosquito plant feeding. These …

Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae)

P Moyo, P Kunyane, MA Selepe, JN Eloff, J Niemand… - Malaria journal, 2019 - Springer
Background Optimal adoption of the malaria transmission-blocking strategy is currently
limited by lack of safe and efficacious drugs. This has sparked the exploration of different …

Semisynthesis of Novel Dispiro-pyrrolizidino/thiopyrrolizidino-oxindolo/indanedione Natural Product Hybrids of Parthenin Followed by Their Cytotoxicity Evaluation

CP Singh, P Sharma, M Ahmed, D Kumar… - ACS …, 2023 - ACS Publications
Natural products possess unique and broader intricacies in the chemical space and have
been essential for drug discovery. The crucial factor for drug discovery success is not the …

Derivatization increases mosquito larvicidal activity of the sesquiterpene lactone parthenin isolated from the invasive weed Parthenium hysterophorus

TK Milugo, DP Tchouassi, RA Kavishe… - Pest Management …, 2021 - Wiley Online Library
BACKGROUND Extracts of the invasive weed Parthenium hysterophorus (Asteraceae) have
been shown to possess larvicidal activity against a wide range of disease vectors. However …