Clonal haematopoiesis and dysregulation of the immune system
Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
Clonal hematopoiesis and its impact on human health
Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells
(HSCs), leading to clonal haematopoiesis. These lesions are precursors for blood cancers …
(HSCs), leading to clonal haematopoiesis. These lesions are precursors for blood cancers …
Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia
CA Lachowiez, N Long, J Saultz, A Gandhi… - Blood …, 2023 - ashpublications.org
Risk stratification in acute myeloid leukemia (AML) remains principle in survival
prognostication and treatment selection. The 2022 European LeukemiaNet (ELN) …
prognostication and treatment selection. The 2022 European LeukemiaNet (ELN) …
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in
blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP) …
blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP) …
Are deep learning structural models sufficiently accurate for virtual screening? application of docking algorithms to AlphaFold2 predicted structures
AM Díaz-Rovira, H Martín, T Beuming… - Journal of Chemical …, 2023 - ACS Publications
Machine learning-based protein structure prediction algorithms, such as RosettaFold and
AlphaFold2, have greatly impacted the structural biology field, arousing a fair amount of …
AlphaFold2, have greatly impacted the structural biology field, arousing a fair amount of …
Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke
Clonal hematopoiesis (CH) is common among older people and is associated with an
increased risk of atherosclerosis, inflammation, and shorter overall survival. Age and …
increased risk of atherosclerosis, inflammation, and shorter overall survival. Age and …
Unidirectional association of clonal hematopoiesis with atherosclerosis development
M Díez-Díez, BL Ramos-Neble, J de la Barrera… - Nature Medicine, 2024 - nature.com
Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …
Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures
B Diamond, B Ziccheddu, K Maclachlan… - Blood, The Journal …, 2023 - ashpublications.org
Patients treated with cytotoxic therapies, including autologous stem cell transplantation, are
at risk for developing therapy-related myeloid neoplasms (tMN). Preleukemic clones (ie …
at risk for developing therapy-related myeloid neoplasms (tMN). Preleukemic clones (ie …
[HTML][HTML] Understanding the impact of feedback regulations on blood cell production and leukemia dynamics using model analysis and simulation of clinically relevant …
Acute myeloid leukemia (AML) is a paradigmatic example of a stem cell-driven cancer. AML
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …